The new tool more accurately distinguishes mutations that drive cancer from ones that don’t, and could help focus future research and drug development.
A clinical study comparing liquid and tissue biopsies finds multiple resistance mechanisms in individual patients, which could explain why targeted therapies often fail.
Through the Ó³»´«Ã½â€™s Cancer Dependency Map, researchers are searching for genetic vulnerabilities in cancer cells that could lead the way to better precision drugs.
By matching cells' growth trajectories to their genetic features, a team finds CLL cells' arc of growth is written into their genes early in disease development.
By probing the molecular basis of proteasome inhibitor resistance in cancer cells, a Ó³»´«Ã½-led team finds new vulnerability — and compounds that exploit it.
In a #WhyIScience Q&A, the longtime group leader from the Ó³»´«Ã½â€™s Cancer Program recounts his move from molecular to computational biology and talks about the collaborative effort that went into The Cancer Genome Atlas