A team studying rare kidney diseases pivoted to lung injury and identified an FDA-approved drug that’s now being tested as a potential COVID-19 treatment.
Researchers find that several genetic disorders, including MUC1 kidney disease, may share a novel molecular mechanism — and identify a promising therapeutic lead.
The ӳý Cancer Dependency Map team adds CRISPR-based data from 342 cancer cell lines to their growing catalog of genetic dependencies in cancer, and a new method for ensuring that data's accuracy.
While mutations in protein-coding genes have held the limelight in cancer genomics, those in the noncoding genome (home to the regulatory elements that control gene activity) may also have powerful roles in driving tumor growth. A new study reveals recurrent mutations in nine such noncoding elements in breast cancer.
Launched in partnership with , the center brings together researchers from the ӳý, the Carlos Slim Health Institute, other research institutions in Mexico, and elsewhere with a shared commitment to transform human health.
Although type 2 diabetes is a major public health problem across the globe, Latin American countries carry a disproportionately heavy burden (relative rates of type 2 diabetes by country shown in purple above). ӳý researchers and their collaborators have discovered a strong genetic risk factor for type 2 diabetes that primarily affects Latin American patients, but is rare elsewhere.
Researchers from the Boston area, Mexico, and Norway have completed a comprehensive genomic analysis of cervical cancer in two patient populations. The study identified recurrent genetic mutations not previously found in cervical cancer, including at least one for which targeted treatments have been approved for other forms of cancer. The findings also shed light on the role human papillomavirus (HPV) plays in the development of cervical cancer.
An international team of researchers in Mexico and the United States has uncovered a new genetic clue that contributes to an increased risk of developing type 2 diabetes, particularly the elevated risk among Mexican and other Latin American populations.