News 06.30.2023 New image-based cellular profiling tool peers deeply into metabolic biology LipocyteProfiler captures disease-relevant phenotypes in an inexpensive microscopy assay Imaging Platform Metabolism Program Connecting variants to functions Cardiovascular disease Diabetes Obesity Heart Disease Image-Based Profiling Read more
News 05.25.2023 Study finds how a genetic variant raises diabetes risk through an unexpected mechanism The variant contributes to a unique form of diabetes by reducing fat cells' ability to store fat and respond to insulin Metabolism Program Diabetes Connecting variants to functions Read more
News 05.02.2023 Researchers use base editing to probe blood cell biology By editing individual DNA “letters” in blood cells, scientists better understand the molecular underpinnings of some genetic diseases. Connecting variants to functions Read more
News 09.19.2022 ӳý Discovery Center in Cambridge opens to the public this October Visitors are invited to explore galleries highlighting key discoveries and transformative insights in biomedicine. Gerstner Center for Cancer Diagnostics NeuroGap Precision Cardiology Laboratory Cancer Program Chemical Biology and Therapeutics Science Program Genetic Perturbation Program Imaging Platform Medical and Population Genetics Program Metabolism Program Infectious Disease and Microbiome Program ... Read more
News 05.06.2022 Exploring autoimmunity's regulatory roots Using a pair of high-throughput approaches, researchers sift genome-wide data for key non-coding variants influencing immune function. Cell Circuits Program Immunological Disease Connecting variants to functions Read more
News 02.02.2022 Three autism risk genes have similar effects on brain development, but by different routes Harvard and ӳý researchers use miniature 3D models of the human brain to study the biological functions of genetic risk factors Klarman Cell Observatory Stanley Center for Psychiatric Research Brain Health Connecting variants to functions Psychiatric disease Read more
News 01.20.2022 New high-throughput method greatly expands view of how mutations impact cells ӳý scientists have developed a new approach for studying the functional effects of the millions of mutations associated with cancer and other diseases Cancer Program Klarman Cell Observatory Connecting variants to functions Cancer Gene-Expression Profiling Single Cell Aviv Regev Regev Lab Read more
News 04.07.2021 New maps link thousands of genetic variants to disease genes The maps can help researchers figure out the function of genes and mechanisms of diseases including inflammatory bowel disease. Lander Lab Connecting variants to functions Read more
News 12.03.2020 Large-scale tool helps reveal function of autism spectrum disorder genes Scientists apply the “Perturb-Seq” method to a living organism for the first time Klarman Cell Observatory Stanley Center for Psychiatric Research Connecting variants to functions Gene editing CRISPR Aviv Regev Read more
News 09.10.2020 GTEx Consortium releases fresh insights into how DNA differences govern gene expression Fifteen studies establish a resource & outline outcomes of the consortium's 10-year effort to explain how DNA variants found in large-scale genetic research influence traits and disease Aggregating and harmonizing data Connecting variants to functions Gene-Expression Profiling Read more