Regular program meetings draw participants from many research communities to share cutting-edge research and brainstorm new project ideas in a wide variety of fields relevant to chemical biology and therapeutics science.
If you are interested in nominating a speaker for a meeting, please contact us at CBTS-central@broadinstitute.org.
2024-2025 Speakers
04/16/2025 | TBA | Carolina Ortiz Cordero Kiessling Lab |
04/16/2025 | TBA | Ankit Basak Kiessling Lab |
04/02/2025 | TBA | Itay Algov Zhou Lab |
03/19/2025 | Chemical Mimicry between a Molecular Glue and E3 Ligase Cancer Mutations | Megan Yeo & Olivia Zhang Liau Lab |
01/22/2025 | Identification of a cryptic allosteric site on the E3 ligase adapter protein cereblon | Vanessa Dippon Woo Lab |
01/22/2025 | Discovery of small molecule splicing modulators that disrupt O-GlcNAc homeostasis from a drug repurposing screen | Steven Cheng Woo Lab |
12/11/2024 | When less is more: Ultrasensitive HDX-MS workflows for high-throughput analysis of proteins and their interactors | Shaunak Raval Proteomics Platform |
12/11/2024 | Turning up the Heat on Target Discovery: unbiased identification of cellular protein drug targets with thermal profiling | Keith Rivera Proteomics Platform |
12/04/2024 | E3-substrate tagging by ubiquitin biotinylation | Hubert Huang Sellers Lab |
12/04/2024 | High-Throughput in Silico Genetic Screen for Discovering Novel Genoma Regulations | Bio Xia Xia Lab |
11/13/2024 | Spatially resolved single-cell genomics and cell atlas of the brain | Meng Zhang Zhuang Lab |
10/23/2024 | Light-directed evolution of dynamic and multi-state proteins | Sahand Rahi EPFL |
10/02/2024 | Covalent Stabilization of Ternary Complexes for Cell-Cell "Induced Proximity" | Anthony Rullo McMaster Immunology Research Center |
09/04/2024 | Protein semisynthesis reveals plasticity in HECT E3 ubiquitin ligase mechanisms | Hanjie Jiang Cole Lab |
09/04/2024 | Engineering tumor-specific PROTACs in MDM2-amplified cancers | Sam Bevill Qi Lab |
2023-2024 Speakers
03/13/2024 | Hit identification using DNA-encoded library (DEL) screening and machine learning (ML) methods - DEL+ML approaches | Sumaiya Iqbal & Holly Soutter CDoT |
02/28/2024 | Bifunctional Small Molecules That Induce Targeted Protein Relocalization and Targeted Transcriptional Regulation | Will Gibson Schreiber Lab |
02/28/2024 | Pharmacological Targeting of the Transcription Factor - IRF4 | Mike Agius Qi Lab |
02/14/2024 | Imaging mass spectrometry at subcellular spatial resolution with the NanoSIMS: What it can and cannot do | Christelle Guillermier Cole Lab |
02/14/2024 | Uncoupling Histone Modification Crosstalk by Engineering Lysine Demethylase LSD1 | Kwangwoon "Jon" Lee Cole Lab |
01/17/2024 | Shedding light on the dark matter of viral proteomes to advance our understanding of antiviral immunity | Shira Weingarten-Gabbay Sabeti Lab |
11/08/2023 | Cell-Permeable Anti-CRISPR Proteins for Precision Genome Editing | Axel Vera Raines/Choudhary Lab |
11/08/2023 | Gene Therapy Without the Genes: Intracellular Delivery of Therapeutic Proteins via Traceless Bioreversible Esterification Strategy | Joomyung "Vicky" Jun Raines Lab |
10/25/2023 | Continuous evolution of compact protein degradation tags regulated by selective cereblon molecular glues | Jaron Mercer & Shourya Roy Burman Liu Lab and Fischer Lab |
10/11/2023 | Optogenetic polymerization of functional materials for modulation of single neuron excitability | Chanan Sessler Wang Lab |
10/11/2023 | Targeted Degradation of Membrane Proteins: Transferrin Receptor Targeting Chimeras (TransTACs) | Kaitlin Rhee Zhou Lab |
Past Speakers
03/13/2024 | Hit identification using DNA-encoded library (DEL) screening and machine learning (ML) methods - DEL+ML approaches | Sumaiya Iqbal & Holly Soutter CDoT |
02/28/2024 | Bifunctional Small Molecules That Induce Targeted Protein Relocalization and Targeted Transcriptional Regulation | Will Gibson Schreiber Lab |
02/28/2024 | Pharmacological Targeting of the Transcription Factor - IRF4 | Mike Agius Qi Lab |
02/14/2024 | Imaging mass spectrometry at subcellular spatial resolution with the NanoSIMS: What it can and cannot do | Christelle Guillermier Cole Lab |
02/14/2024 | Uncoupling Histone Modification Crosstalk by Engineering Lysine Demethylase LSD1 | Kwangwoon "Jon" Lee Cole Lab |
01/17/2024 | Shedding light on the dark matter of viral proteomes to advance our understanding of antiviral immunity | Shira Weingarten-Gabbay Sabeti Lab |
11/08/2023 | Cell-Permeable Anti-CRISPR Proteins for Precision Genome Editing | Axel Vera Raines/Choudhary Lab |
11/08/2023 | Gene Therapy Without the Genes: Intracellular Delivery of Therapeutic Proteins via Traceless Bioreversible Esterification Strategy | Joomyung "Vicky" Jun Raines Lab |
10/25/2023 | Continuous evolution of compact protein degradation tags regulated by selective cereblon molecular glues | Jaron Mercer & Shourya Roy Burman Liu Lab and Fischer Lab |
10/11/2023 | Optogenetic polymerization of functional materials for modulation of single neuron excitability | Chanan Sessler Wang Lab |
10/11/2023 | Targeted Degradation of Membrane Proteins: Transferrin Receptor Targeting Chimeras (TransTACs) | Kaitlin Rhee Zhou Lab |
06/21/2023 | Understanding Human GeneticVariation with Precision Genome Editing Tools | Alexis Komor UCSD |
06/07/2023 | Leveraging Dendritic Cell Lectin Engagement to Develop Effective Cancer Vaccines | Valerie Lensch & Adele Gabba Kiessling Lab |
05/24/2023 | Functional diversification of plant small molecules by the gut microbiome tunes intestinal homeostasis | Gavin Kuziel Rakoff-Nahoum Lab |
04/26/2023 | Flavoaffinins: a family of elusive bacterial pigments implicated in efficient anaerobic digestion of cellulose | Duncan Kountz Balskus Lab |
01/18/2023 | Encoding chemicals and assays with DNA: Applications in Medicinal Chemistry and Biology | Casey Krusemark Purdue University |
12/07/2022 | Schizophrenia and bipolar disorder: from human genetics towards mechanisms and therapeutics | Morgan Sheng Stanley Center |
11/16/2022 | Structural insights into the LSD1 N-terminus using hydrogen/deuterium exchange-mass spectrometry | Malvinaa Papanastasiou Proteomics Platform |
11/16/2022 | The LSD1 N-terminus modulates transcription factor partitioning and enhancer decommissioning | Amanda Waterbury Liau Lab |
11/02/2022 | Designing ligand-binding proteins from scratch | Nicholas Polizzi DFCI |
11/02/2022 | Characterizing biological electron transfer to bio-inspired polymers | Alec Agee Furst Lab |
10/19/2022 | Designing new protein functions for proteoform editing and biosensing | Xin Zhou DFCI |
10/19/2022 | Engineering point-of-care electrochemical diagnostics for infectious diseases​ | Xingcheng "Cindy" Zhou Furst Lab |
10/05/2022 | Development of a bifunctional protein tag to advance targeted protein degradation research | Breanne Zerfas DFCI |
10/05/2022 | Untargeted metabolomics reveals novel metabolic markers for T cell activation | Conghui Yao Haigis Lab |
09/21/2022 | Smelling the glucose: Stimulating insulin secretion through olfactory receptor activation | Amedeo Vetere Wagner Lab |