Fernando DM, Gee CT, Griffith EC, et al. Biophysical analysis of the Mycobacteria tuberculosis peptide binding protein DppA reveals a stringent peptide binding pocket. Tuberculosis (Edinb). 2022;132:102157. doi:10.1016/j.tube.2021.102157
Center for the Development of Therapeutics
Parker E, Cain B, Hajian B, et al. An Iterative Approach Guides Discovery of the FabI Inhibitor Fabimycin, a Late-Stage Antibiotic Candidate with Efficacy against Drug-Resistant Gram-Negative Infections. ACS central science. 2022;8(8):1145-1158. doi:10.1021/acscentsci.2c00598
Shekhar M, Gupta C, Suzuki K, Chan C, Murata T, Singharoy A. Revealing a Hidden Intermediate of Rotatory Catalysis with X-ray Crystallography and Molecular Simulations. ACS central science. 2022;8(7):915-925. doi:10.1021/acscentsci.1c01599
Chandrasekaran SN, Cimini BA, Goodale A, et al. Three million images and morphological profiles of cells treated with matched chemical and genetic perturbations. bioRxiv. 2022. doi:10.1101/2022.01.05.475090
Miller P, Sathappa M, Moroco J, et al. Allosteric inhibition of PPM1D serine/threonine phosphatase via an altered conformational state. Nature communications. 2022;13(1):3778. doi:10.1038/s41467-022-30463-9
Orsi D, Pook E, Bräuer N, et al. Discovery and Structure-Based Design of Potent Covalent PPARγ Inverse-Agonists and . Journal of medicinal chemistry. 2022;65(21):14843-14863. doi:10.1021/acs.jmedchem.2c01379
Bondeson D, Mullin-Bernstein Z, Oliver S, et al. Systematic profiling of conditional degron tag technologies for target validation studies. Nature communications. 2022;13(1):5495. doi:10.1038/s41467-022-33246-4
DeJarnette C, Meyer CJ, Jenner AR, et al. Identification of Inhibitors of Fungal Fatty Acid Biosynthesis. ACS Infect Dis. 2021;7(12):3210-3223. doi:10.1021/acsinfecdis.1c00404
Ito T, Young MJ, Li R, et al. Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers. Nat Genet. 2021;53(12):1664-1672. doi:10.1038/s41588-021-00967-z
Wang JS, Kamath T, Mazur CM, et al. Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin. Nat Commun. 2021;12(1):6271. doi:10.1038/s41467-021-26571-7