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Metabolomics Platform

Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages.

Palsson-McDermott EM, Curtis AM, Goel G, et al. Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages. Cell Metab. 2015;21(1):65-80. doi:10.1016/j.cmet.2014.12.005

Modulators of hepatic lipoprotein metabolism identified in a search for small-molecule inducers of tribbles pseudokinase 1 expression.

Nagiec MM, Skepner AP, Negri J, et al. Modulators of hepatic lipoprotein metabolism identified in a search for small-molecule inducers of tribbles pseudokinase 1 expression. PLoS One. 2015;10(3):e0120295. doi:10.1371/journal.pone.0120295

Metabolomic profiling in the prediction of gestational diabetes mellitus.

Bentley-Lewis R, Huynh J, Xiong G, et al. Metabolomic profiling in the prediction of gestational diabetes mellitus. Diabetologia. 2015;58(6):1329-32. doi:10.1007/s00125-015-3553-4

HdhQ111 Mice Exhibit Tissue Specific Metabolite Profiles that Include Striatal Lipid Accumulation.

Carroll JB, Deik A, Fossale E, et al. HdhQ111 Mice Exhibit Tissue Specific Metabolite Profiles that Include Striatal Lipid Accumulation. PLoS One. 2015;10(8):e0134465. doi:10.1371/journal.pone.0134465

Tuberous sclerosis complex 2 loss increases lysophosphatidylcholine synthesis in lymphangioleiomyomatosis.

Priolo C, Ricoult SJH, Khabibullin D, et al. Tuberous sclerosis complex 2 loss increases lysophosphatidylcholine synthesis in lymphangioleiomyomatosis. American journal of respiratory cell and molecular biology. 2015;53(1):33-41. doi:10.1165/rcmb.2014-0379RC

Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages.

Palsson-McDermott EM, Curtis AM, Goel G, et al. Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages. Cell metabolism. 2015;21(2):347. doi:10.1016/j.cmet.2015.01.017

Effects of sodium benzoate, a widely used food preservative, on glucose homeostasis and metabolic profiles in humans.

Lennerz BS, Vafai SB, Delaney NF, et al. Effects of sodium benzoate, a widely used food preservative, on glucose homeostasis and metabolic profiles in humans. Mol Genet Metab. 2015;114(1):73-9. doi:10.1016/j.ymgme.2014.11.010

Erratum: Distinct metabolomic signatures are associated with longevity in humans.

Cheng S, Larson MG, McCabe EL, et al. Erratum: Distinct metabolomic signatures are associated with longevity in humans. Nature communications. 2015;6:7317. doi:10.1038/ncomms8317

5-hydroxymethylcytosine is not present in appreciable quantities in Arabidopsis DNA.

Erdmann RM, Souza AL, Clish CB, Gehring M. 5-hydroxymethylcytosine is not present in appreciable quantities in Arabidopsis DNA. G3 (Bethesda). 2014;5(1):1-8. doi:10.1534/g3.114.014670

Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development.

Mayers JR, Wu C, Clish CB, et al. Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development. Nat Med. 2014;20(10):1193-8. doi:10.1038/nm.3686