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Proteomics Platform

PEPPeR, a platform for experimental proteomic pattern recognition.

Jaffe JD, Mani DR, Leptos KC, Church GM, Gillette MA, Carr SA. PEPPeR, a platform for experimental proteomic pattern recognition. Mol Cell Proteomics. 2006;5(10):1927-41. doi:10.1074/mcp.M600222-MCP200

The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease.

Lamb J, Crawford ED, Peck D, et al. The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease. Science. 2006;313(5795):1929-35. doi:10.1126/science.1132939

mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s.

Frias MA, Thoreen CC, Jaffe JD, et al. mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s. Curr Biol. 2006;16(18):1865-70. doi:10.1016/j.cub.2006.08.001

Protein biomarker discovery and validation: the long and uncertain path to clinical utility.

Rifai N, Gillette MA, Carr SA. Protein biomarker discovery and validation: the long and uncertain path to clinical utility. Nat Biotechnol. 2006;24(8):971-83. doi:10.1038/nbt1235

Systematic identification of human mitochondrial disease genes through integrative genomics.

Calvo S, Jain M, Xie X, et al. Systematic identification of human mitochondrial disease genes through integrative genomics. Nat Genet. 2006;38(5):576-82. doi:10.1038/ng1776

Place of pattern in proteomic biomarker discovery.

Gillette MA, Mani DR, Carr SA. Place of pattern in proteomic biomarker discovery. J Proteome Res. 2005;4(4):1143-54. doi:10.1021/pr0500962

Mapping posttranslational modifications of proteins by MS-based selective detection: application to phosphoproteomics.

Carr S, Annan R, Huddleston M. Mapping posttranslational modifications of proteins by MS-based selective detection: application to phosphoproteomics. Methods in enzymology. 2005;405:82-115. doi:10.1016/S0076-6879(05)05005-6

Selective detection of glycopeptides on ion trap mass spectrometers.

Sullivan B, Addona TA, Carr SA. Selective detection of glycopeptides on ion trap mass spectrometers. Anal Chem. 2004;76(11):3112-8. doi:10.1021/ac035427d

Determination of the gamma-2 phase in a South African dispersed phase amalgam alloy.

Sarkar NK, Wiltshire WA. Determination of the gamma-2 phase in a South African dispersed phase amalgam alloy. J Dent Assoc S Afr. 1988;43(5):193-5.