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Stanley Center for Psychiatric Research

Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging.

Liang SH, Chen JM, Normandin MD, et al. Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging. Angew Chem Int Ed Engl. 2016;55(33):9601-5. doi:10.1002/anie.201603797

Differential dopaminergic regulation of inwardly rectifying potassium channel mediated subthreshold dynamics in striatal medium spiny neurons.

Zhao B, Zhu J, Dai D, et al. Differential dopaminergic regulation of inwardly rectifying potassium channel mediated subthreshold dynamics in striatal medium spiny neurons. Neuropharmacology. 2016;107:396-410. doi:10.1016/j.neuropharm.2016.03.037

Microglia contribute to circuit defects in Mecp2 null mice independent of microglia-specific loss of Mecp2 expression.

Schafer DP, Heller CT, Gunner G, et al. Microglia contribute to circuit defects in Mecp2 null mice independent of microglia-specific loss of Mecp2 expression. Elife. 2016;5. doi:10.7554/eLife.15224

Microglia: Phagocytosing to Clear, Sculpt, and Eliminate.

Hong S, Stevens B. Microglia: Phagocytosing to Clear, Sculpt, and Eliminate. Dev Cell. 2016;38(2):126-8. doi:10.1016/j.devcel.2016.07.006

Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-Wide Selectivity and Their Functional Effects.

Wagner FF, Bishop JA, Gale JP, et al. Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-Wide Selectivity and Their Functional Effects. ACS Chem Biol. 2016;11(7):1952-63. doi:10.1021/acschembio.6b00306

Unbiased Deep Sequencing of RNA Viruses from Clinical Samples.

Matranga CB, Gladden-Young A, Qu J, et al. Unbiased Deep Sequencing of RNA Viruses from Clinical Samples. J Vis Exp. 2016;(113). doi:10.3791/54117

A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases.

Han B, Pouget JG, Slowikowski K, et al. A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases. Nat Genet. 2016;48(7):803-10. doi:10.1038/ng.3572

Genome-wide Association Studies of Posttraumatic Stress Disorder in 2 Cohorts of US Army Soldiers.

Stein MB, Chen CY, Ursano RJ, et al. Genome-wide Association Studies of Posttraumatic Stress Disorder in 2 Cohorts of US Army Soldiers. JAMA Psychiatry. 2016;73(7):695-704. doi:10.1001/jamapsychiatry.2016.0350

A complement-microglial axis drives synapse loss during virus-induced memory impairment.

Vasek MJ, Garber C, Dorsey D, et al. A complement-microglial axis drives synapse loss during virus-induced memory impairment. Nature. 2016;534(7608):538-43. doi:10.1038/nature18283

Large-Scale Production of Mature Neurons from Human Pluripotent Stem Cells in a Three-Dimensional Suspension Culture System.

Rigamonti A, Repetti GG, Sun C, et al. Large-Scale Production of Mature Neurons from Human Pluripotent Stem Cells in a Three-Dimensional Suspension Culture System. Stem Cell Reports. 2016;6(6):993-1008. doi:10.1016/j.stemcr.2016.05.010