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PURPOSE: We investigated visual field (VF) archetype-genotype associations for open-angle glaucoma (OAG) and its subtypes, high-tension glaucoma (HTG) and normal-tension glaucoma (NTG).DESIGN: Cross-sectional, population-based study.PARTICIPANTS: A total of 80,651 VFs from 11,572 OAG patients (H40.1x) at Massachusetts Eye and Ear (2012-2022) were used to identify VF archetypes. Archetype-genotype correlations were performed on participants with genotyping data, VFs, and OAG codes (H40.1x) from the Mass General Brigham Biobank, and three health professional cohorts (n=1,495) with primary open-angle glaucoma (POAG) and reproducible VF loss.METHODS: POAG polygenic risk score (PRS), NTG PRS, and weighted HTG genetic risk score (GRS) from genome-wide association studies were calculated for 1,495 participants (2,062 eyes). Logistic regression assessed VF archetype-genotype associations, adjusting for age, sex, and ancestry.MAIN OUTCOME MEASURES: The association between PRS/GRS and VF archetypes.RESULTS: Nine archetypes (AT) were identified, including normal (AT1) and various paracentral, peripheral, and total loss patterns. In a logistic regression model adjusted for age, sex, and ancestry, a one standard deviation (SD) increase in POAG PRS was linked to 1.65-times higher odds of paracentral (aOR=1.65, 95% CI 1.32-2.08) and 1.30-times higher odds of peripheral defects (aOR=1.3, 95% CI 1.14-1.48). A one SD increase in NTG PRS was associated with 1.69-times higher odds of paracentral (aOR=1.69, 95% CI 1.23-2.3) and 1.28-times higher odds of peripheral defects (aOR=1.28, 95% CI 1.06-1.54). A one SD increase in HTG GRS was linked to 0.68-times lower odds of both paracentral (aOR=0.68, 95% CI 0.57-0.82) and peripheral defects (aOR=0.68, 95% CI 0.62-0.76). A one SD increase in HTG GRS was also associated with 1.31-times higher odds of total loss (OR=1.31, 95% CI 1.01-1.77) in an unadjusted model, but was not significant in the adjusted model (aOR=1.15, 95% CI 0.87-1.57).CONCLUSION: Higher POAG PRS and NTG PRS were associated with paracentral VF loss, while higher HTG GRS was linked to total VF loss but not paracentral defects. Genetic risk for glaucoma subtypes is associated with specific VF defects, which may affect disease diagnosis and prognostication.