Safeguarding genomic imprints in naive human pluripotency.
Stem cell reports
| Authors | |
| Abstract | Naive human pluripotent stem cells (hPSCs) closely mirror the pre-implantation epiblast but risk imprint erosion under strong MEK/ERK inhibition, jeopardizing disease modeling and regenerative applications. In Stem Cell Reports, Fischer et al. show that partial MEK/ERK inhibition plus ZFP57 overexpression crucially preserves parent-of-origin DNA methylation, thereby offering more faithful and stable naive hPSC models. |
| Year of Publication | 2025
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| Journal | Stem cell reports
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| Pages | 102475
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| Date Published | 03/2025
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| ISSN | 2213-6711
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| DOI | 10.1016/j.stemcr.2025.102475
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| PubMed ID | 40250437
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