Selective optical drive of thalamic reticular nucleus generates thalamic bursts and cortical spindles.

Nat Neurosci

Authors	Michael Halassa Joshua Siegle Jason Ritt Jonathan Ting Guoping Feng Christopher Moore
Keywords	Animals Mice Mice, Inbred C57BL Bacterial Proteins Neurons Mice, Transgenic Electroencephalography Patch-Clamp Techniques Somatosensory Cortex Brain Mapping Rhodopsin Neural Pathways Luminescent Proteins Light Microscopy, Confocal Imaging, Three-Dimensional Action Potentials Thalamic Nuclei Glutamate Decarboxylase Electromyography Vesicular Inhibitory Amino Acid Transport Proteins Evoked Potentials, Somatosensory Optical Devices
Abstract	The thalamic reticular nucleus (TRN) is hypothesized to regulate neocortical rhythms and behavioral states. Using optogenetics and multi-electrode recording in behaving mice, we found that brief selective drive of TRN switched the thalamocortical firing mode from tonic to bursting and generated state-dependent neocortical spindles. These findings provide causal support for the involvement of the TRN in state regulation in vivo and introduce a new model for addressing the role of this structure in behavior.
Year of Publication	2011
Journal	Nat Neurosci
Volume	14
Issue	9
Pages	1118-20
Date Published	2011 Jul 24
ISSN	1546-1726
DOI	10.1038/nn.2880
PubMed ID	21785436
PubMed Central ID	PMC4169194
Links
Grant list	R01 NS045130 / NS / NINDS NIH HHS / United States R01 NS045130-05A2 / NS / NINDS NIH HHS / United States R25 MH094612 / MH / NIMH NIH HHS / United States R01 NS045130-05 / NS / NINDS NIH HHS / United States