The nature of confounding in genome-wide association studies.

Nat Rev Genet
Authors
Keywords
Abstract

The authors argue that population structure per se is not a problem in genome-wide association studies - the true sources are the environment and the genetic background, and the latter is greatly underappreciated. They conclude that mixed models effectively address this issue.

Year of Publication
2013
Journal
Nat Rev Genet
Volume
14
Issue
1
Pages
1-2
Date Published
2013 Jan
ISSN
1471-0064
URL
DOI
10.1038/nrg3382
PubMed ID
23165185
Links
Grant list
HG002790 / HG / NHGRI NIH HHS / United States