CD33 modulates TREM2: convergence of Alzheimer loci.
Nat Neurosci
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| Abstract | We used a protein quantitative trait analysis in monocytes from 226 individuals to evaluate cross-talk between Alzheimer loci. The NME8 locus influenced PTK2B and the CD33 risk allele led to greater TREM2 expression. There was also a decreased TREM1/TREM2 ratio with a TREM1 risk allele, decreased TREM2 expression with CD33 suppression and elevated cortical TREM2 mRNA expression with amyloid pathology. |
| Year of Publication | 2015
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| Journal | Nat Neurosci
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| Volume | 18
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| Issue | 11
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| Pages | 1556-8
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| Date Published | 2015 Nov
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| ISSN | 1546-1726
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| URL | |
| DOI | 10.1038/nn.4126
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| PubMed ID | 26414614
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| PubMed Central ID | PMC4682915
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| Grant list | U01 AG046152 / AG / NIA NIH HHS / United States
R01 AG17917 / AG / NIA NIH HHS / United States
RF1 AG015819 / AG / NIA NIH HHS / United States
K25 AG041906 / AG / NIA NIH HHS / United States
P01 AG036694 / AG / NIA NIH HHS / United States
R01 AG043617 / AG / NIA NIH HHS / United States
R01 AG017917 / AG / NIA NIH HHS / United States
P30 AG10161 / AG / NIA NIH HHS / United States
U01 AG46152 / AG / NIA NIH HHS / United States
P50 AG005134 / AG / NIA NIH HHS / United States
P30 AG010161 / AG / NIA NIH HHS / United States
R01 AG15819 / AG / NIA NIH HHS / United States
R01 AG048015 / AG / NIA NIH HHS / United States
R01 AG036836 / AG / NIA NIH HHS / United States
R01 AG015819 / AG / NIA NIH HHS / United States
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