Identification and characterization of latency-associated peptide-expressing γδ T cells.
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Abstract | γδ T cells are a subset of lymphocytes specialized in protecting the host against pathogens and tumours. Here we describe a subset of regulatory γδ T cells that express the latency-associated peptide (LAP), a membrane-bound TGF-β1. Thymic CD27+IFN-γ+CCR9+α4β7+TCRγδ+ cells migrate to the periphery, particularly to Peyer's patches and small intestine lamina propria, where they upregulate LAP, downregulate IFN-γ via ATF-3 expression and acquire a regulatory phenotype. TCRγδ+LAP+ cells express antigen presentation molecules and function as antigen presenting cells that induce CD4+Foxp3+ regulatory T cells, although TCRγδ+LAP+ cells do not themselves express Foxp3. Identification of TCRγδ+LAP+ regulatory cells provides an avenue for understanding immune regulation and biologic processes linked to intestinal function and disease. |
Year of Publication | 2015
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Journal | Nat Commun
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Volume | 6
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Pages | 8726
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Date Published | 2015 Dec 08
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ISSN | 2041-1723
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URL | |
DOI | 10.1038/ncomms9726
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PubMed ID | 26644347
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PubMed Central ID | PMC4686827
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Grant list | R01 AG043975 / AG / NIA NIH HHS / United States
R01 AI043458 / AI / NIAID NIH HHS / United States
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