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Publications

K-mer analysis of long-read alignment pileups for structural variant genotyping.

English AC, Cunial F, Metcalf GA, Gibbs RA, Sedlazeck FJ. K-mer analysis of long-read alignment pileups for structural variant genotyping. bioRxiv : the preprint server for biology. 2024. doi:10.1101/2024.10.22.619642

Comprehensive structure-function analysis reveals gain- and loss-of-function mechanisms impacting oncogenic KRAS activity.

Kwon JJ, Dilly J, Liu S, et al. Comprehensive structure-function analysis reveals gain- and loss-of-function mechanisms impacting oncogenic KRAS activity. bioRxiv : the preprint server for biology. 2024. doi:10.1101/2024.10.22.618529

Spatiotemporal lineage tracing reveals the dynamic spatial architecture of tumor growth and metastasis.

Jones MG, Sun D, Min KHJ, et al. Spatiotemporal lineage tracing reveals the dynamic spatial architecture of tumor growth and metastasis. bioRxiv : the preprint server for biology. 2024. doi:10.1101/2024.10.21.619529

A framework for target discovery in rare cancers.

Li B, Sadagopan A, Li J, et al. A framework for target discovery in rare cancers. bioRxiv : the preprint server for biology. 2024. doi:10.1101/2024.10.24.620074

Evolutionary-Scale Enzymology Enables Biochemical Constant Prediction Across a Multi-Peaked Catalytic Landscape.

Muir DF, Asper GPR, Notin P, et al. Evolutionary-Scale Enzymology Enables Biochemical Constant Prediction Across a Multi-Peaked Catalytic Landscape. bioRxiv : the preprint server for biology. 2024. doi:10.1101/2024.10.23.619915

Site of breast cancer metastasis is independent of single nutrient levels.

Abbott KL, Subudhi S, Ferreira R, et al. Site of breast cancer metastasis is independent of single nutrient levels. bioRxiv : the preprint server for biology. 2024. doi:10.1101/2024.10.24.616714

Biophysical metabolic modeling of complex bacterial colony morphology.

Dukovski I, Golden L, Zhang J, Osborne M, Segrè D, Korolev KS. Biophysical metabolic modeling of complex bacterial colony morphology. bioRxiv : the preprint server for biology. 2024. doi:10.1101/2024.03.13.584915

Primary Open-Angle Glaucoma Polygenic Risk Score and Risk of Disease Onset: A Post Hoc Analysis of a Randomized Clinical Trial.

Sekimitsu S, Ghazal N, Aziz K, et al. Primary Open-Angle Glaucoma Polygenic Risk Score and Risk of Disease Onset: A Post Hoc Analysis of a Randomized Clinical Trial. JAMA ophthalmology. 2024. doi:10.1001/jamaophthalmol.2024.4376

Continuous evolution of user-defined genes at 1 million times the genomic mutation rate.

Rix G, Williams RL, Hu VJ, et al. Continuous evolution of user-defined genes at 1 million times the genomic mutation rate. Science (New York, N.Y.). 2024;386(6722):eadm9073. doi:10.1126/science.adm9073

Opportunities for Therapeutic Modulation of O-GlcNAc.

Cheng SS, Mody AC, Woo CM. Opportunities for Therapeutic Modulation of O-GlcNAc. Chemical reviews. 2024. doi:10.1021/acs.chemrev.4c00417