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Publications

Introducing a G-Makassar variant in HSCs by in vivo base editing treats sickle cell disease in mice.

Li C, Georgakopoulou A, Paschoudi K, et al. Introducing a G-Makassar variant in HSCs by in vivo base editing treats sickle cell disease in mice. Molecular therapy : the journal of the American Society of Gene Therapy. 2024. doi:10.1016/j.ymthe.2024.10.018

Empowering biomedical discovery with AI agents.

Gao S, Fang A, Huang Y, et al. Empowering biomedical discovery with AI agents. Cell. 2024;187(22):6125-6151. doi:10.1016/j.cell.2024.09.022

Genetics of Latin American Diversity Project: Insights into population genetics and association studies in admixed groups in the Americas.

Borda V, Loesch DP, Guo B, et al. Genetics of Latin American Diversity Project: Insights into population genetics and association studies in admixed groups in the Americas. Cell genomics. 2024:100692. doi:10.1016/j.xgen.2024.100692

Finding the right friends: Stromal composition influences TLS formation in ovarian cancer.

Bod L. Finding the right friends: Stromal composition influences TLS formation in ovarian cancer. Cancer cell. 2024. doi:10.1016/j.ccell.2024.10.004

Degradation of IKZF1 prevents epigenetic progression of T cell exhaustion in an antigen-specific assay.

Tay T, Bommakanti G, Jaensch E, et al. Degradation of IKZF1 prevents epigenetic progression of T cell exhaustion in an antigen-specific assay. Cell reports. Medicine. 2024:101804. doi:10.1016/j.xcrm.2024.101804

Distinct Escherichia coli transcriptional profiles in the guts of recurrent UTI sufferers revealed by pangenome hybrid selection.

Young MG, Straub TJ, Worby CJ, et al. Distinct Escherichia coli transcriptional profiles in the guts of recurrent UTI sufferers revealed by pangenome hybrid selection. Nature communications. 2024;15(1):9466. doi:10.1038/s41467-024-53829-7

HiDDEN: a machine learning method for detection of disease-relevant populations in case-control single-cell transcriptomics data.

Goeva A, Dolan MJ, Luu J, et al. HiDDEN: a machine learning method for detection of disease-relevant populations in case-control single-cell transcriptomics data. Nature communications. 2024;15(1):9468. doi:10.1038/s41467-024-53666-8

Plasma protein-based organ-specific aging and mortality models unveil diseases as accelerated aging of organismal systems.

Goeminne LJE, Vladimirova A, Eames A, et al. Plasma protein-based organ-specific aging and mortality models unveil diseases as accelerated aging of organismal systems. Cell metabolism. 2024. doi:10.1016/j.cmet.2024.10.005

Clinical and Genomic Features of Classical and Basal Transcriptional Subtypes in Pancreatic Cancer.

Singh H, Xiu J, Kapner KS, et al. Clinical and Genomic Features of Classical and Basal Transcriptional Subtypes in Pancreatic Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2024;30(21):4932-4942. doi:10.1158/1078-0432.CCR-24-1164

Proteogenomic analysis integrated with electronic health records data reveals disease-associated variants in Black Americans.

Tahir UA, Barber JL, Cruz DE, et al. Proteogenomic analysis integrated with electronic health records data reveals disease-associated variants in Black Americans. The Journal of clinical investigation. 2024;134(21). doi:10.1172/JCI181802