Publications

Effective targeting of PDGFRA-altered high-grade glioma with avapritinib.

Mayr L, Neyazi S, Schwark K, et al. Effective targeting of PDGFRA-altered high-grade glioma with avapritinib. Cancer cell. 2025. doi:10.1016/j.ccell.2025.02.018

Accurate fusion transcript identification from long- and short-read isoform sequencing at bulk or single-cell resolution.

Qin Q, Popic V, Wienand K, et al. Accurate fusion transcript identification from long- and short-read isoform sequencing at bulk or single-cell resolution. Genome research. 2025. doi:10.1101/gr.279200.124

Biosurfer for systematic tracking of regulatory mechanisms leading to protein isoform diversity.

Murali M, Saquing J, Lu S, et al. Biosurfer for systematic tracking of regulatory mechanisms leading to protein isoform diversity. Genome research. 2025. doi:10.1101/gr.279317.124

Social disadvantage accelerates aging.

Kivimaki M, Pentti J, Frank P, et al. Social disadvantage accelerates aging. Nature medicine. 2025. doi:10.1038/s41591-025-03563-4

A single-nucleus and spatial transcriptomic atlas of the COVID-19 liver reveals topological, functional, and regenerative organ disruption in patients.

Pita-Juárez Y, Karagkouni D, Kalavros N, et al. A single-nucleus and spatial transcriptomic atlas of the COVID-19 liver reveals topological, functional, and regenerative organ disruption in patients. Genome biology. 2025;26(1):56. doi:10.1186/s13059-025-03499-5

Comprehensive proteomics metadata and integrative web portals facilitate sharing and integration of LINCS multiomics data.

Vidovic D, Shamsaei B, Schürer SC, et al. Comprehensive proteomics metadata and integrative web portals facilitate sharing and integration of LINCS multiomics data. Molecular & cellular proteomics : MCP. 2025:100947. doi:10.1016/j.mcpro.2025.100947

Heterogeneous effects of genetic variants and traits associated with fasting insulin on cardiometabolic outcomes.

Sevilla-Gonzalez M, Smith K, Wang N, et al. Heterogeneous effects of genetic variants and traits associated with fasting insulin on cardiometabolic outcomes. Nature communications. 2025;16(1):2569. doi:10.1038/s41467-025-57452-y

Rare missense variants of the leukocyte common antigen related receptor (LAR) display reduced activity in transcellular adhesion and synapse formation.

Kaas M, Chofflet N, Bicer D, et al. Rare missense variants of the leukocyte common antigen related receptor (LAR) display reduced activity in transcellular adhesion and synapse formation. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.02.16.638491

Multi-omic analysis of the ciliogenic transcription factor reveals a role in promoting activity-dependent responses via enhancing CREB binding in human neurons.

Lai J, Demirbas D, Phillips K, et al. Multi-omic analysis of the ciliogenic transcription factor reveals a role in promoting activity-dependent responses via enhancing CREB binding in human neurons. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.02.27.640588

Parts and ICRAFTs: Finding new immunotherapy targets.

Bi K, Yates KB. Parts and ICRAFTs: Finding new immunotherapy targets. Immunity. 2025;58(3):529-531. doi:10.1016/j.immuni.2025.02.016

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Publications

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