Session Videos

On September 22 and 23, 2011, the ӳ��ý's Stanley Center for Psychiatric Research and MIT's McGovern and Picower Institutes co-hosted a symposium on the emerging genetics and neurobiology of severe mental illness. 350 people attended the symposium, which included more than 30 talks and invigorating discussion. Videos from these presentations and the Q&A sessions that followed are available for viewing below.

Day 1: Genetics

Session 1: Genetics of Schizophrenia and Bipolar Illness Chair: Steven McCarroll
	Copy number variants and the genetics of schizophrenia and bipolar disorder Jonathan Sebat, University Of California, San Diego	[ video ]
	Schizophrenia genetics: new insights from new mutations Maria Karayiorgou, Columbia University	[ -NA- ]
	*Analysis of de novo* CNV mutations in schizophrenia implicates specific post-synaptic protein complexes** Michael O’Donovan, School of Medicine, Cardiff University	[ video ]
	Exome sequencing in schizophrenia Shaun Purcell, ӳ��ý/Massachusetts General Hospital	[ video ]
	GWAS analysis across five psychiatric illnesses. Results of a combined dataset power of more than 60,000 individuals Stephan Ripke, ӳ��ý/Massachusetts General Hospital	[ video ]
	Bipolar disorder genetics from the Psychiatric GWAS Consortium Pamela Sklar, Mt. Sinai School of Medicine	[ -NA- ]
	Interacting genes and interacting environments in risk for schizophrenia Daniel Weinberger, National Institutes of Mental Health/Lieber Institute	[ video ]
Session 2: Genetics of Autism, OCD, Depression and Mental Retardation Chair: Mriganka Sur
	Homing in on the allelic architecture of autism spectrum disorders Matthew State, Yale University	Available November 2011
	Synaptic and circuitry mechanisms of compulsive/repetitive behaviors in OCD and autism Guoping Feng, MIT (McGovern Institute)	[ video ]
	Genetics of major depression: What to do next? Patrick Sullivan, University of North Carolina	[ video ]
	Autism: Rare causes of an increasingly common disorder Christopher A. Walsh, Children's Hospital – Boston	[ video ]
	*Quantifying the role of de novo* point mutations in autism** Ben Neale, ӳ��ý/Massachusetts General Hospital	[ video ]
	Human genome structural variation, disease and evolution Evan Eichler, University of Washington	[ video ]
	Modeling neuropsychiatric disorders in the mouse Mario Capecchi, University of Utah	[ video ]
Day 2: Biology and Clinical
Session 3: Emerging Biology and Functional Data Chair: Mark Bear
	Late breaking topic: Discovering autosomal recessive subtypes in autism Elaine Lim, Harvard Medical School/Mass General Hospital/ӳ��ý	[ video ]
	What we need from gene discovery to advance biological insight Mark Daly, Massachusetts General Hospital/ӳ��ý	[ video ]
	Cpg2, a risk gene for bipolar disorder, encodes a regulator of glutamate receptor endocytosis Elly Nedivi, MIT (Picower Institute)	[ -NA- ]
	Examining the genetics of bipolar disorder using human induced neurons Li-Huei Tsai, MIT (Picower Institute)	[ -NA- ]
	Controlling brain circuits with light: Towards systematic analysis of neural circuit functions Ed Boyden, MIT (Media Lab)	[ video ]
	Mapping depression circuits: Foundation for new treatment strategies using direct brain stimulation Helen Mayberg, Emory University	[ video ]
	Modeling psychiatric disorders through reprogramming Rusty Gage, Salk Institute	[ video ]
	Using human iPSC derived neural cells to understand bipolar disorder Jon Madison, Stanley Center, ӳ��ý	[ video ]
	At the core of autism: Models of 16p11.2 copy number variation Alea Mills, Cold Spring Harbor Laboratory	[ -NA- ]
Session 4: Clinical Applications Chair: Ed Scolnick
	Genetic risk prediction for mental illness: Prospects and limitations Peter Visscher, Queensland Institute of Medical Research	[ video ]
	Allosteric modulators of GPCRs as a novel approach for treatment of severe mental illness Jeff Conn, Vanderbilt Medical Center	[ video ]
	HDACs in memory and cognition: Development of isoform selective inhibitors with improved CNS drug properties Ed Holson, Stanley Center, ӳ��ý	[ video ]
	PDE10 inhibitors as potential schizophrenia drugs Sasha Gragerov, Omeros	[ video ]
	Rapid acting antidepressants increase mTOR signaling and synaptogenesis Ronald Duman, Yale University	[ video ]
	Discovery of a neuroprotective chemical Steve McKnight, University of Texas Southwestern Medical Center	[ video ]
	Novartis AFQ056/mavoglurant early phase clinical trial results Baltazar Gomez-Mancilla, Novartis	[ video ]
	Closing remarks Steve Hyman, Harvard University	[ video ]