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Seminar series

The Cell Circuits & Epigenomics programs host a weekly seminar series at the ӳ����ý for affiliated members on anything and everything to do with genome biology and cell circuitry. If you would like to be added to the distribution list, please email cce-admin@broadinstitute.org

Check out and share our growing library of Cell Circuits & Epigenomics Primers:

Michael Bronstein is a professor at Imperial College London and University of Lugano and Head of Graph Learning Research at Twitter.

Travis Hughes: “Seq-Well: A portable, low cost platform for single-cell RNA-sequencing of low input samples”

Anne Carpenter: “The ӳ����ý Imaging Platform”

ENCODE Project - ӳ����ýE

In May 2020, the Epigenomics team partnered with the ӳ����ýE Workshop Series to present the second annual, virtual version of the . In this four-part recording of the workshop, you'll learn how to access and work with data via both the ENCODE portal and Search Candidate cis-Regulatory Elements by ENCODE (SCREEN) from leaders from the National Human Genome Research Institute and ӳ����ý’s partners at the Stanford ENCODE data coordination center and the University of Massachusetts data analysis center. Check it out!

Learn more about the epigenome

Five questions for Brad Bernstein
Brad Bernstein answered five questions posed by the ӳ����ýMinded blog about epigenomics and his work to develop .

Brad Bernstein explains the epigenome
In this ӳ����ýView video, Epigenomics Program director Brad Bernstein explains the epigenome and the role it plays in cancer development.

Research news from the Epigenomics Program

Deciphering chromatin: Many marks, millions of histones at a time
A new high-resolution technique for reading combinations of chemical flags in the epigenome, reported in , could help uncover new rules underlying cell fate and provide important clues for understanding diseases like cancer.

Enhancer hijacking means a power-up for salivary gland cancer
In , Yotam Drier, Birgit Knoechel, Brad Bernstein, and other colleagues, explore the implications of a special kind of translocation — one that repositions an oncogene, its promoter, and a nearby super-enhancer as a single unit — in adenoid cystic carcinoma.

For drivers of Alzheimer’s disease, check the roadmap
To understand the impact of gene regulation in Alzheimer’s disease (AD), a team of researchers led by Manolis Kellis mapped the epigenetic landscape of AD-associated neurodegeneration, reporting their findings in .

Glioblastoma’s “stem-like” cells laid bare
In a paper in , a team led by Mario Suva, Esther Rheinbay, and Brad Bernstein described a network of genes controlled in glioblastoma by four transcription factors, as well as insights into potential therapeutic strategies.

Insights into drug resistance for a rare leukemia
A team led by Brigit Knoechel and Brad Bernstein report in that an epigenetic factor, BRD4, plays a crucial role in the ability of T-cell acute lymphoblastic leukemia (T-ALL) cells to resist treatment with NOTCH1 inhibitors.

Editing the epigenome
A team of researchers from the Epigenomics Program and MGH reported in their efforts to develop a TAL effector-based method to test the functions of suspected enhancers by homing in on their signature epigenomic marks.

Rewinding the clock with epigenomics
In a review article in , Brad Bernstein, Mario Suvà, and Nicolo Riggi describe deep insights gained about features shared between oncogenesis, induced pluripotency, and directed differentiation.

Epigenomics approach illuminates the dark corners of the genome
ӳ����ý researchers described in the use of a computational technique to predict the function in some of the non-coding parts of the genome in human T cells.

The machinery of chromatin regulation
Oren Ram, Alon Goren, Aviv Regev, Brad Bernstein, and colleagues reveal in that specific combinations of chromatin regulator proteins control essential chromatin activities, like histone modification.

ӳ����ý awarded major grant to bolster epigenomics research
The Epigenomics Program received a five-year, ~$15 million grant designating the institute to become one of four NIH Roadmap for Medical Research Reference Epigenome Mapping Center nationwide.

Gaining ground on glioblastoma
Certain regulatory proteins play a major role in the “self-renewing” cancer stem cells that drive glioblastoma growth, according to research published in by Esther Rheinbay, Mario L. Suvà, Brad Bernstein, and colleagues.

ӳ����ý epigenetics research makes a big splash
An analysis of four methylation mapping approaches revealed that the four methods all produce accurate DNA methylation data, but differ in the ability to detect regions that are methylated differently.