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Metabolomics Platform

Metabolic modeling of single Th17 cells reveals regulators of autoimmunity.

Wagner A, Wang C, Fessler J, et al. Metabolic modeling of single Th17 cells reveals regulators of autoimmunity. Cell. 2021;184(16):4168-4185.e21. doi:10.1016/j.cell.2021.05.045

Fatty acid synthesis is required for breast cancer brain metastasis.

Ferraro GB, Ali A, Luengo A, et al. Fatty acid synthesis is required for breast cancer brain metastasis. Nature cancer. 2021;2(4):414-428. doi:10.1038/s43018-021-00183-y

SIRT4 is an early regulator of branched-chain amino acid catabolism that promotes adipogenesis.

Zaganjor E, Yoon H, Spinelli JB, et al. SIRT4 is an early regulator of branched-chain amino acid catabolism that promotes adipogenesis. Cell reports. 2021;36(2):109345. doi:10.1016/j.celrep.2021.109345

Adaptation of pancreatic cancer cells to nutrient deprivation is reversible and requires glutamine synthetase stabilization by mTORC1.

Tsai PY, Lee MS, Jadhav U, et al. Adaptation of pancreatic cancer cells to nutrient deprivation is reversible and requires glutamine synthetase stabilization by mTORC1. Proceedings of the National Academy of Sciences of the United States of America. 2021;118(10). doi:10.1073/pnas.2003014118

Metabolomics of the tryptophan-kynurenine degradation pathway and risk of atrial fibrillation and heart failure: potential modification effect of Mediterranean diet.

Razquin C, Ruiz-Canela M, Toledo E, et al. Metabolomics of the tryptophan-kynurenine degradation pathway and risk of atrial fibrillation and heart failure: potential modification effect of Mediterranean diet. The American journal of clinical nutrition. 2021;114(5):1646-1654. doi:10.1093/ajcn/nqab238

Metabolomic profiling identifies complex lipid species and amino acid analogues associated with response to weight loss interventions.

Bihlmeyer NA, Kwee LC, Clish CB, et al. Metabolomic profiling identifies complex lipid species and amino acid analogues associated with response to weight loss interventions. PloS one. 2021;16(5):e0240764. doi:10.1371/journal.pone.0240764

Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program.

Taliun D, Harris DN, Kessler MD, et al. Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program. Nature. 2021;590(7845):290-299. doi:10.1038/s41586-021-03205-y

Regulation of purine metabolism connects KCTD13 to a metabolic disorder with autistic features.

Madison JM, Duong K, Vieux EF, et al. Regulation of purine metabolism connects KCTD13 to a metabolic disorder with autistic features. iScience. 2021;24(1):101935. doi:10.1016/j.isci.2020.101935

Plasma Metabolomic Signatures of Healthy Dietary Patterns in the Chronic Renal Insufficiency Cohort (CRIC) Study.

Kim H, Anderson CA, Hu EA, et al. Plasma Metabolomic Signatures of Healthy Dietary Patterns in the Chronic Renal Insufficiency Cohort (CRIC) Study. The Journal of nutrition. 2021;151(10):2894-2907. doi:10.1093/jn/nxab203

Genetic and non-genetic factors affecting the expression of COVID-19-relevant genes in the large airway epithelium.

Kasela S, Ortega VE, Martorella M, et al. Genetic and non-genetic factors affecting the expression of COVID-19-relevant genes in the large airway epithelium. Genome medicine. 2021;13(1):66. doi:10.1186/s13073-021-00866-2