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Metabolomics Platform

An Integrative Transcriptomic and Metabolomic Study of Lung Function in Children With Asthma.

Kelly RS, Chawes BL, Blighe K, et al. An Integrative Transcriptomic and Metabolomic Study of Lung Function in Children With Asthma. Chest. 2018;154(2):335-348. doi:10.1016/j.chest.2018.05.038

Dietary Intakes and Circulating Concentrations of Branched-Chain Amino Acids in Relation to Incident Type 2 Diabetes Risk Among High-Risk Women with a History of Gestational Diabetes Mellitus.

Tobias DK, Clish C, Mora S, et al. Dietary Intakes and Circulating Concentrations of Branched-Chain Amino Acids in Relation to Incident Type 2 Diabetes Risk Among High-Risk Women with a History of Gestational Diabetes Mellitus. Clin Chem. 2018;64(8):1203-1210. doi:10.1373/clinchem.2017.285841

Nitric Oxide Engages an Anti-inflammatory Feedback Loop Mediated by Peroxiredoxin 5 in Phagocytes.

Graham DB, Jasso GJ, Mok A, et al. Nitric Oxide Engages an Anti-inflammatory Feedback Loop Mediated by Peroxiredoxin 5 in Phagocytes. Cell Rep. 2018;24(4):838-850. doi:10.1016/j.celrep.2018.06.081

Early loss of mitochondrial complex I and rewiring of glutathione metabolism in renal oncocytoma.

Gopal RK, Calvo SE, Shih AR, et al. Early loss of mitochondrial complex I and rewiring of glutathione metabolism in renal oncocytoma. Proc Natl Acad Sci U S A. 2018;115(27):E6283-E6290. doi:10.1073/pnas.1711888115

Plasma Tryptophan-Kynurenine Metabolites Are Altered in Human Immunodeficiency Virus Infection and Associated With Progression of Carotid Artery Atherosclerosis.

Qi Q, Hua S, Clish CB, et al. Plasma Tryptophan-Kynurenine Metabolites Are Altered in Human Immunodeficiency Virus Infection and Associated With Progression of Carotid Artery Atherosclerosis. Clin Infect Dis. 2018;67(2):235-242. doi:10.1093/cid/ciy053

Plasma branched chain/aromatic amino acids, enriched Mediterranean diet and risk of type 2 diabetes: case-cohort study within the PREDIMED Trial.

Ruiz-Canela M, Guasch-Ferré M, Toledo E, et al. Plasma branched chain/aromatic amino acids, enriched Mediterranean diet and risk of type 2 diabetes: case-cohort study within the PREDIMED Trial. Diabetologia. 2018;61(7):1560-1571. doi:10.1007/s00125-018-4611-5

Plasma trimethylamine-N-oxide and related metabolites are associated with type 2 diabetes risk in the Prevención con Dieta Mediterránea (PREDIMED) trial.

Papandreou C, Bulló M, Zheng Y, et al. Plasma trimethylamine-N-oxide and related metabolites are associated with type 2 diabetes risk in the Prevención con Dieta Mediterránea (PREDIMED) trial. Am J Clin Nutr. 2018;108(1):163-173. doi:10.1093/ajcn/nqy058

Altered exocrine function can drive adipose wasting in early pancreatic cancer.

Danai LV, Babic A, Rosenthal MH, et al. Altered exocrine function can drive adipose wasting in early pancreatic cancer. Nature. 2018;558(7711):600-604. doi:10.1038/s41586-018-0235-7

Cerebral tryptophan metabolism and outcome of tuberculous meningitis: an observational cohort study.

van Laarhoven A, Dian S, Aguirre-Gamboa R, et al. Cerebral tryptophan metabolism and outcome of tuberculous meningitis: an observational cohort study. Lancet Infect Dis. 2018;18(5):526-535. doi:10.1016/S1473-3099(18)30053-7

Ablation of insulin receptor substrates 1 and 2 suppresses -driven lung tumorigenesis.

Xu H, Lee MS, Tsai PY, et al. Ablation of insulin receptor substrates 1 and 2 suppresses -driven lung tumorigenesis. Proc Natl Acad Sci U S A. 2018;115(16):4228-4233. doi:10.1073/pnas.1718414115