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Metabolomics Platform

Unbiased Metabolite Profiling of Schizophrenia Fibroblasts under Stressful Perturbations Reveals Dysregulation of Plasmalogens and Phosphatidylcholines.

Huang JH, Park H, Iaconelli J, et al. Unbiased Metabolite Profiling of Schizophrenia Fibroblasts under Stressful Perturbations Reveals Dysregulation of Plasmalogens and Phosphatidylcholines. J Proteome Res. 2017;16(2):481-493. doi:10.1021/acs.jproteome.6b00628

Starved epithelial cells uptake extracellular matrix for survival.

Muranen T, Iwanicki MP, Curry NL, et al. Starved epithelial cells uptake extracellular matrix for survival. Nat Commun. 2017;8:13989. doi:10.1038/ncomms13989

Metabolites Associated With Lean Mass and Adiposity in Older Black Men.

Murphy RA, Moore SC, Playdon M, et al. Metabolites Associated With Lean Mass and Adiposity in Older Black Men. J Gerontol A Biol Sci Med Sci. 2017. doi:10.1093/gerona/glw245

Identifying the metabolomic fingerprint of high and low flavonoid consumers.

Ivey KL, Rimm EB, Kraft P, et al. Identifying the metabolomic fingerprint of high and low flavonoid consumers. Journal of nutritional science. 2017;6:e34. doi:10.1017/jns.2017.27

Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity.

Arts RJW, Novakovic B, Horst RT, et al. Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity. Cell Metab. 2016;24(6):807-819. doi:10.1016/j.cmet.2016.10.008

Cell culture-based profiling across mammals reveals DNA repair and metabolism as determinants of species longevity.

Ma S, Upneja A, Galecki A, et al. Cell culture-based profiling across mammals reveals DNA repair and metabolism as determinants of species longevity. Elife. 2016;5. doi:10.7554/eLife.19130

Metabolites of Glutamate Metabolism Are Associated With Incident Cardiovascular Events in the PREDIMED PREvención con DIeta MEDiterránea (PREDIMED) Trial.

Zheng Y, Hu FB, Ruiz-Canela M, et al. Metabolites of Glutamate Metabolism Are Associated With Incident Cardiovascular Events in the PREDIMED PREvención con DIeta MEDiterránea (PREDIMED) Trial. J Am Heart Assoc. 2016;5(9). doi:10.1161/JAHA.116.003755

Revealing disease-associated pathways by network integration of untargeted metabolomics.

Pirhaji L, Milani P, Leidl M, et al. Revealing disease-associated pathways by network integration of untargeted metabolomics. Nat Methods. 2016;13(9):770-6. doi:10.1038/nmeth.3940

Perturbational Profiling of Metabolites in Patient Fibroblasts Implicates α-Aminoadipate as a Potential Biomarker for Bipolar Disorder.

Huang JH, Berkovitch SS, Iaconelli J, et al. Perturbational Profiling of Metabolites in Patient Fibroblasts Implicates α-Aminoadipate as a Potential Biomarker for Bipolar Disorder. Mol Neuropsychiatry. 2016;2(2):97-106. doi:10.1159/000446654

Targeting MTHFD2 in acute myeloid leukemia.

Pikman Y, Puissant A, Alexe G, et al. Targeting MTHFD2 in acute myeloid leukemia. J Exp Med. 2016;213(7):1285-306. doi:10.1084/jem.20151574