ӳ��ý

Proteomics Platform

Cell-specific transcriptional control of mitochondrial metabolism by TIF1γ drives erythropoiesis.

Rossmann MP, Hoi K, Chan V, et al. Cell-specific transcriptional control of mitochondrial metabolism by TIF1γ drives erythropoiesis. Science. 2021;372(6543):716-721. doi:10.1126/science.aaz2740

Epigenetic silencing by SETDB1 suppresses tumour intrinsic immunogenicity.

Griffin GK, Wu J, Iracheta-Vellve A, et al. Epigenetic silencing by SETDB1 suppresses tumour intrinsic immunogenicity. Nature. 2021. doi:10.1038/s41586-021-03520-4

Avadomide induces degradation of ZMYM2 fusion oncoproteins in hematologic malignancies.

Renneville A, Gasser JA, Grinshpun DE, et al. Avadomide induces degradation of ZMYM2 fusion oncoproteins in hematologic malignancies. Blood Cancer Discov. 2021;2(3):250-265. doi:10.1158/2643-3230.bcd-20-0105

Proteomics of protein trafficking by in vivo tissue-specific labeling.

Droujinine IA, Meyer AS, Wang D, et al. Proteomics of protein trafficking by in vivo tissue-specific labeling. Nat Commun. 2021;12(1):2382. doi:10.1038/s41467-021-22599-x

Suppression of pancreatic ductal adenocarcinoma growth and metastasis by fibrillar collagens produced selectively by tumor cells.

Tian C, Huang Y, Clauser KR, et al. Suppression of pancreatic ductal adenocarcinoma growth and metastasis by fibrillar collagens produced selectively by tumor cells. Nat Commun. 2021;12(1):2328. doi:10.1038/s41467-021-22490-9

Blockade of IL-22 signaling reverses erythroid dysfunction in stress-induced anemias.

Raundhal M, Ghosh S, Myers SA, et al. Blockade of IL-22 signaling reverses erythroid dysfunction in stress-induced anemias. Nat Immunol. 2021;22(4):520-529. doi:10.1038/s41590-021-00895-4

Proteomic profiling reveals biomarkers and pathways in type 2 diabetes risk.

Ngo D, Benson MD, Long JZ, et al. Proteomic profiling reveals biomarkers and pathways in type 2 diabetes risk. JCI Insight. 2021;6(5). doi:10.1172/jci.insight.144392

Biomarkers to distinguish bacterial from viral pediatric clinical pneumonia in a malaria endemic setting.

Gillette MA, Mani DR, Uschnig C, et al. Biomarkers to distinguish bacterial from viral pediatric clinical pneumonia in a malaria endemic setting. Clin Infect Dis. 2021. doi:10.1093/cid/ciaa1843

Dual functions of SPOP and ERG dictate androgen therapy responses in prostate cancer.

Bernasocchi T, Tekle GE, Bolis M, et al. Dual functions of SPOP and ERG dictate androgen therapy responses in prostate cancer. Nat Commun. 2021;12(1):734. doi:10.1038/s41467-020-20820-x

Noncanonical open reading frames encode functional proteins essential for cancer cell survival.

Prensner JR, Enache OM, Luria V, et al. Noncanonical open reading frames encode functional proteins essential for cancer cell survival. Nat Biotechnol. 2021. doi:10.1038/s41587-020-00806-2