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Cancer Program

Are CRISPR Screens Providing the Next Generation of Therapeutic Targets?

Vazquez F, Sellers WR. Are CRISPR Screens Providing the Next Generation of Therapeutic Targets?. Cancer Res. 2021;81(23):5806-5809. doi:10.1158/0008-5472.CAN-21-1784

Racial, Ethnic, and Socioeconomic Disparities in Curative Treatment Receipt and Survival in Hepatocellular Carcinoma.

Wagle NS, Park S, Washburn D, et al. Racial, Ethnic, and Socioeconomic Disparities in Curative Treatment Receipt and Survival in Hepatocellular Carcinoma. Hepatol Commun. 2021. doi:10.1002/hep4.1863

Biologically informed deep neural network for prostate cancer discovery.

Elmarakeby HA, Hwang J, Arafeh R, et al. Biologically informed deep neural network for prostate cancer discovery. Nature. 2021;598(7880):348-352. doi:10.1038/s41586-021-03922-4

Parallel Genomic Alterations of Antigen and Payload Targets Mediate Polyclonal Acquired Clinical Resistance to Sacituzumab Govitecan in Triple-Negative Breast Cancer.

Coates JT, Sun S, Leshchiner I, et al. Parallel Genomic Alterations of Antigen and Payload Targets Mediate Polyclonal Acquired Clinical Resistance to Sacituzumab Govitecan in Triple-Negative Breast Cancer. Cancer Discov. 2021;11(10):2436-2445. doi:10.1158/2159-8290.CD-21-0702

Duplex-Repair enables highly accurate sequencing, despite DNA damage.

Xiong K, Shea D, Rhoades J, et al. Duplex-Repair enables highly accurate sequencing, despite DNA damage. Nucleic Acids Res. 2021. doi:10.1093/nar/gkab855

Molecular Alterations in Pediatric Low-Grade Gliomas That Led to Death.

Ahrendsen JT, Sinai C, Meredith DM, et al. Molecular Alterations in Pediatric Low-Grade Gliomas That Led to Death. J Neuropathol Exp Neurol. 2021. doi:10.1093/jnen/nlab097

TISMO: syngeneic mouse tumor database to model tumor immunity and immunotherapy response.

Zeng Z, Wong CJ, Yang L, et al. TISMO: syngeneic mouse tumor database to model tumor immunity and immunotherapy response. Nucleic Acids Res. 2021. doi:10.1093/nar/gkab804

The challenges in treating Embryonal Tumors with Multilayered Rosettes (ETMR) and other infant brain tumors.

Bandopadhayay P, Chi SN. The challenges in treating Embryonal Tumors with Multilayered Rosettes (ETMR) and other infant brain tumors. Neuro Oncol. 2021. doi:10.1093/neuonc/noab206

Telomerase as a therapeutic target in glioblastoma.

Aquilanti E, Kageler L, Wen PY, Meyerson M. Telomerase as a therapeutic target in glioblastoma. Neuro Oncol. 2021. doi:10.1093/neuonc/noab203

Molecular basis for substrate recruitment to the PRMT5 methylosome.

Mulvaney KM, Blomquist C, Acharya N, et al. Molecular basis for substrate recruitment to the PRMT5 methylosome. Mol Cell. 2021;81(17):3481-3495.e7. doi:10.1016/j.molcel.2021.07.019