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Stanley Center for Psychiatric Research

Phenome-wide association studies across large population cohorts support drug target validation.

Diogo D, Tian C, Franklin CS, et al. Phenome-wide association studies across large population cohorts support drug target validation. Nat Commun. 2018;9(1):4285. doi:10.1038/s41467-018-06540-3

CD47 Protects Synapses from Excess Microglia-Mediated Pruning during Development.

Lehrman EK, Wilton DK, Litvina EY, et al. CD47 Protects Synapses from Excess Microglia-Mediated Pruning during Development. Neuron. 2018;100(1):120-134.e6. doi:10.1016/j.neuron.2018.09.017

Microglia and the Brain: Complementary Partners in Development and Disease.

Hammond TR, Robinton D, Stevens B. Microglia and the Brain: Complementary Partners in Development and Disease. Annu Rev Cell Dev Biol. 2018;34:523-544. doi:10.1146/annurev-cellbio-100616-060509

Posttraumatic stress disorder and development of premenstrual syndrome in a longitudinal cohort of women.

Jung SJ, Roberts AL, Chocano-Bedoya P, et al. Posttraumatic stress disorder and development of premenstrual syndrome in a longitudinal cohort of women. Arch Womens Ment Health. 2018. doi:10.1007/s00737-018-0916-0

Functional equivalence of genome sequencing analysis pipelines enables harmonized variant calling across human genetics projects.

Regier AA, Farjoun Y, Larson DE, et al. Functional equivalence of genome sequencing analysis pipelines enables harmonized variant calling across human genetics projects. Nat Commun. 2018;9(1):4038. doi:10.1038/s41467-018-06159-4

Multi-Trait Analysis of GWAS and Biological Insights Into Cognition: A Response to Hill (2018).

Lam M, Trampush JW, Yu J, et al. Multi-Trait Analysis of GWAS and Biological Insights Into Cognition: A Response to Hill (2018). Twin Res Hum Genet. 2018;21(5):394-397. doi:10.1017/thg.2018.46

Gene therapy for neurological disorders: progress and prospects.

Deverman BE, Ravina BM, Bankiewicz KS, Paul SM, W Y Sah D. Gene therapy for neurological disorders: progress and prospects. Nat Rev Drug Discov. 2018;17(10):767. doi:10.1038/nrd.2018.158

Thrombospondin receptor α2δ-1 promotes synaptogenesis and spinogenesis via postsynaptic Rac1.

Risher C, Kim N, Koh S, et al. Thrombospondin receptor α2δ-1 promotes synaptogenesis and spinogenesis via postsynaptic Rac1. J Cell Biol. 2018;217(10):3747-3765. doi:10.1083/jcb.201802057

Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk.

Reshef YA, Finucane HK, Kelley DR, et al. Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk. Nat Genet. 2018;50(10):1483-1493. doi:10.1038/s41588-018-0196-7

The contribution of CACNA1A, ATP1A2 and SCN1A mutations in hemiplegic migraine: A clinical and genetic study in Finnish migraine families.

Hiekkala ME, Vuola P, Artto V, et al. The contribution of CACNA1A, ATP1A2 and SCN1A mutations in hemiplegic migraine: A clinical and genetic study in Finnish migraine families. Cephalalgia. 2018;38(12):1849-1863. doi:10.1177/0333102418761041