Mouse ooplasm confers context-specific reprogramming capacity.
Nat Genet
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| Abstract | Enucleated oocytes have the distinctive ability to reprogram somatic nuclei back to totipotency. Here, we investigate genome-scale DNA methylation patterns after nuclear transfer and compare them to the dynamics at fertilization. We identify specific targets for DNA demethylation after nuclear transfer, such as germline-associated promoters, as well as unique limitations that include certain repetitive element classes. |
| Year of Publication | 2012
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| Journal | Nat Genet
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| Volume | 44
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| Issue | 9
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| Pages | 978-80
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| Date Published | 2012 Sep
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| ISSN | 1546-1718
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| URL | |
| DOI | 10.1038/ng.2382
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| PubMed ID | 22902786
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| PubMed Central ID | PMC3432711
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| Grant list | P01 GM099117 / GM / NIGMS NIH HHS / United States
U01ES017155 / ES / NIEHS NIH HHS / United States
5DP1OD003958 / OD / NIH HHS / United States
DP1 CA174427 / CA / NCI NIH HHS / United States
P01GM099117 / GM / NIGMS NIH HHS / United States
Howard Hughes Medical Institute / United States
P50 HG006193 / HG / NHGRI NIH HHS / United States
U01 ES017155 / ES / NIEHS NIH HHS / United States
DP1 OD003958 / OD / NIH HHS / United States
1P50HG006193 / HG / NHGRI NIH HHS / United States
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