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Publications

N-terminal modification of Histone H3 inhibits H3K27M-mediated loss of H3K27 trimethylation.

Poux N, Zhang DF, Kebede AF, et al. N-terminal modification of Histone H3 inhibits H3K27M-mediated loss of H3K27 trimethylation. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.01.24.634760

Intraspecies associations from strain-rich metagenome samples.

Qu EB, Baker JS, Markey L, et al. Intraspecies associations from strain-rich metagenome samples. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.02.07.636498

BESTDR: Bayesian quantification of mechanism-specific drug response in cell culture.

McDonald TO, Bruno S, Roney JP, Zervantonakis IK, Michor F. BESTDR: Bayesian quantification of mechanism-specific drug response in cell culture. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.02.05.636681

Clinico-genomic features predict distinct metastatic phenotypes in cutaneous melanoma.

Aprati TJ, Day CP, Lee D, et al. Clinico-genomic features predict distinct metastatic phenotypes in cutaneous melanoma. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.01.24.633441

Refining the cis-regulatory grammar learned by sequence-to-activity models by increasing model resolution.

Chandra NA, Hu Y, Buenrostro JD, Mostafavi S, Sasse A. Refining the cis-regulatory grammar learned by sequence-to-activity models by increasing model resolution. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.01.24.634804

Cell signaling pathways discovery from multi-modal data.

He C, Simpson C, Cossentino I, et al. Cell signaling pathways discovery from multi-modal data. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.02.06.636961

Distinguishing new from persistent infections at the strain level using longitudinal genotyping data.

Nickols WA, Schwabl P, Niangaly A, Murphy SC, Crompton PD, Neafsey DE. Distinguishing new from persistent infections at the strain level using longitudinal genotyping data. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.02.06.636982

Discovery of Chirally-dependent Protein -2-Hydroxyglutarylation by D2HG and L2HG.

Zhang Z, Liu YK, Luo Z, et al. Discovery of Chirally-dependent Protein -2-Hydroxyglutarylation by D2HG and L2HG. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.01.24.634716

Heterogeneous constraint and adaptation across the malaria parasite life cycle.

Perkins SA, Neafsey DE, Early AM. Heterogeneous constraint and adaptation across the malaria parasite life cycle. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.02.11.636054

Lysine vitcylation is a vitamin C-derived protein modification that enhances STAT1-mediated immune response.

He X, Wang Q, Cheng X, et al. Lysine vitcylation is a vitamin C-derived protein modification that enhances STAT1-mediated immune response. Cell. 2025. doi:10.1016/j.cell.2025.01.043