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Publications

Genetic architectures of childhood maltreatment and causal influence of childhood maltreatment on health outcomes in adulthood.

Chen TT, Chen CY, Liu CY, et al. Genetic architectures of childhood maltreatment and causal influence of childhood maltreatment on health outcomes in adulthood. Molecular psychiatry. 2025. doi:10.1038/s41380-025-02928-y

Characterization of tumour heterogeneity through segmentation-free representation learning on multiplexed imaging data.

Tan J, Le H, Deng J, et al. Characterization of tumour heterogeneity through segmentation-free representation learning on multiplexed imaging data. Nature biomedical engineering. 2025. doi:10.1038/s41551-025-01348-1

Distinct explanations underlie gene-environment interactions in the UK Biobank.

Durvasula A, Price AL. Distinct explanations underlie gene-environment interactions in the UK Biobank. American journal of human genetics. 2025. doi:10.1016/j.ajhg.2025.01.014

Virtual fragment screening for DNA repair inhibitors in vast chemical space.

Luttens A, Vo DD, Scaletti ER, et al. Virtual fragment screening for DNA repair inhibitors in vast chemical space. Nature communications. 2025;16(1):1741. doi:10.1038/s41467-025-56893-9

Evaluation of polygenic scores for hypertrophic cardiomyopathy in the general population and across clinical settings.

Zheng SL, Jurgens SJ, McGurk KA, et al. Evaluation of polygenic scores for hypertrophic cardiomyopathy in the general population and across clinical settings. Nature genetics. 2025. doi:10.1038/s41588-025-02094-5

Large-scale genome-wide association analyses identify novel genetic loci and mechanisms in hypertrophic cardiomyopathy.

Tadros R, Zheng SL, Grace C, et al. Large-scale genome-wide association analyses identify novel genetic loci and mechanisms in hypertrophic cardiomyopathy. Nature genetics. 2025. doi:10.1038/s41588-025-02087-4

Prediction of early-onset bipolar using electronic health records.

Wang B, Sheu YH, Lee H, Mealer RG, Castro VM, Smoller JW. Prediction of early-onset bipolar using electronic health records. Journal of child psychology and psychiatry, and allied disciplines. 2025. doi:10.1111/jcpp.14131

A window-of-opportunity trial reveals mechanisms of response and resistance to navtemadlin in patients with recurrent glioblastoma.

Rendo V, Lee EQ, Bossi C, et al. A window-of-opportunity trial reveals mechanisms of response and resistance to navtemadlin in patients with recurrent glioblastoma. Science translational medicine. 2025;17(786):eadn6274. doi:10.1126/scitranslmed.adn6274

Reprogrammable RNA-targeting CRISPR systems evolved from RNA toxin-antitoxins.

Zilberzwige-Tal S, Altae-Tran H, Kannan S, et al. Reprogrammable RNA-targeting CRISPR systems evolved from RNA toxin-antitoxins. Cell. 2025. doi:10.1016/j.cell.2025.01.034

Product and trial design considerations on the path towards a vaccine to combat opioid overdose.

Angelidou A, Koster JA, Sherman AC, et al. Product and trial design considerations on the path towards a vaccine to combat opioid overdose. NPJ vaccines. 2025;10(1):35. doi:10.1038/s41541-025-01083-3