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Publications

Clinical utility and implementation of polygenic risk scores for predicting cardiovascular disease.

Schunkert H, Di Angelantonio E, Inouye M, et al. Clinical utility and implementation of polygenic risk scores for predicting cardiovascular disease. European heart journal. 2025. doi:10.1093/eurheartj/ehae649

zol and fai: large-scale targeted detection and evolutionary investigation of gene clusters.

Salamzade R, Tran PQ, Martin C, et al. zol and fai: large-scale targeted detection and evolutionary investigation of gene clusters. Nucleic acids research. 2025;53(3). doi:10.1093/nar/gkaf045

Genetically Predicted IL-18 Inhibition and Risk of Cardiovascular Events: A Mendelian Randomization Study.

Brennan SO, Kelly PJ, Gorey S, et al. Genetically Predicted IL-18 Inhibition and Risk of Cardiovascular Events: A Mendelian Randomization Study. Circulation. 2025;151(5):334-336. doi:10.1161/CIRCULATIONAHA.124.072238

Introducing the Global Alliance for Spatial Technologies (GESTALT).

Plummer JT, Vlachos IS, Martelotto LG. Introducing the Global Alliance for Spatial Technologies (GESTALT). Nature genetics. 2025. doi:10.1038/s41588-024-02066-1

Clonal Hematopoiesis Associates with Prevalent and Incident Cardiometabolic Disease in High-Risk Individuals.

Regan JA, Kwee LC, Nafissi NA, et al. Clonal Hematopoiesis Associates with Prevalent and Incident Cardiometabolic Disease in High-Risk Individuals. medRxiv : the preprint server for health sciences. 2025. doi:10.1101/2025.01.14.25320566

Detailed tandem repeat allele profiling in 1,027 long-read genomes reveals genome-wide patterns of pathogenicity.

Danzi MC, Xu IRL, Fazal S, et al. Detailed tandem repeat allele profiling in 1,027 long-read genomes reveals genome-wide patterns of pathogenicity. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.01.06.631535

Inflammatory disease microbiomes share a functional pathogenicity predicted by C-reactive protein.

Britton GJ, Mogno I, Chen-Liaw A, et al. Inflammatory disease microbiomes share a functional pathogenicity predicted by C-reactive protein. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.01.14.633015

Insights into the Absence of Lymphoma Despite Fulminant Epstein-Barr Virus Infection in Patients with XIAP Deficiency.

Sun Y, Chou J, Dong K, Gygi SP, Gewurz BE. Insights into the Absence of Lymphoma Despite Fulminant Epstein-Barr Virus Infection in Patients with XIAP Deficiency. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.01.17.633616

A Murine Database of Structural Variants Enables the Genetic Architecture of a Spontaneous Murine Lymphoma to be Characterized.

Ren W, Fang Z, Dolzhenko E, et al. A Murine Database of Structural Variants Enables the Genetic Architecture of a Spontaneous Murine Lymphoma to be Characterized. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.01.09.632219

Enabling end-to-end secure federated learning in biomedical research on heterogeneous computing environments with APPFLx.

Hoang TH, Fuhrman J, Klarqvist M, et al. Enabling end-to-end secure federated learning in biomedical research on heterogeneous computing environments with APPFLx. Computational and structural biotechnology journal. 2025;28:29-39. doi:10.1016/j.csbj.2024.12.001