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Efficient, continuous mutagenesis in human cells using a pseudo-random DNA editor.

Chen H, Liu S, Padula S, et al. Efficient, continuous mutagenesis in human cells using a pseudo-random DNA editor. Nat Biotechnol. 2020;38(2):165-168. doi:10.1038/s41587-019-0331-8

Severe neurocognitive and growth disorders due to variation in THOC2, an essential component of nuclear mRNA export machinery.

Kumar R, Gardner A, Homan CC, et al. Severe neurocognitive and growth disorders due to variation in THOC2, an essential component of nuclear mRNA export machinery. Hum Mutat. 2018;39(8):1126-1138. doi:10.1002/humu.23557

High-throughput genetic screen for synaptogenic factors: identification of LRP6 as critical for excitatory synapse development.

Sharma K, Choi SY, Zhang Y, et al. High-throughput genetic screen for synaptogenic factors: identification of LRP6 as critical for excitatory synapse development. Cell Rep. 2013;5(5):1330-41. doi:10.1016/j.celrep.2013.11.008

The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1.

Chantranupong L, Wolfson RL, Orozco JM, et al. The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1. Cell Rep. 2014;9(1):1-8. doi:10.1016/j.celrep.2014.09.014

Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activity.

Fu S, Yalcin A, Lee GY, et al. Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activity. Sci Transl Med. 2015;7(292):292ra98. doi:10.1126/scitranslmed.aaa9134

Functional analysis of rare variants found in schizophrenia implicates a critical role for GIT1-PAK3 signaling in neuroplasticity.

Kim MJ, Biag J, Fass DM, et al. Functional analysis of rare variants found in schizophrenia implicates a critical role for GIT1-PAK3 signaling in neuroplasticity. Mol Psychiatry. 2017;22(3):417-429. doi:10.1038/mp.2016.98

TRAF2 is an NF-κB-activating oncogene in epithelial cancers.

Shen RR, Zhou AY, Kim E, et al. TRAF2 is an NF-κB-activating oncogene in epithelial cancers. Oncogene. 2015;34(2):209-16. doi:10.1038/onc.2013.543

Identification of Orai1 channel inhibitors by using minimal functional domains to screen small molecule microarrays.

Sadaghiani AM, Lee SM, Odegaard JI, et al. Identification of Orai1 channel inhibitors by using minimal functional domains to screen small molecule microarrays. Chem Biol. 2014;21(10):1278-92. doi:10.1016/j.chembiol.2014.08.016

Deficiency of UBE2T, the E2 Ubiquitin Ligase Necessary for FANCD2 and FANCI Ubiquitination, Causes FA-T Subtype of Fanconi Anemia.

Rickman KA, Lach FP, Abhyankar A, et al. Deficiency of UBE2T, the E2 Ubiquitin Ligase Necessary for FANCD2 and FANCI Ubiquitination, Causes FA-T Subtype of Fanconi Anemia. Cell Rep. 2015;12(1):35-41. doi:10.1016/j.celrep.2015.06.014

Single-molecule decoding of combinatorially modified nucleosomes.

Shema E, Jones D, Shoresh N, Donohue L, Ram O, Bernstein BE. Single-molecule decoding of combinatorially modified nucleosomes. Science. 2016;352(6286):717-21. doi:10.1126/science.aad7701