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Macrolactones in diversity-oriented synthesis: preparation of a pilot library and exploration of factors controlling macrocyclization.

Schmidt DR, Kwon O, Schreiber SL. Macrolactones in diversity-oriented synthesis: preparation of a pilot library and exploration of factors controlling macrocyclization. J Comb Chem. 2004;6(2):286-92. doi:10.1021/cc020076m

Synthesis of conformationally constrained 5-fluoro- and 5-hydroxymethanopyrrolidines. Ring-puckered mimics of gauche- and anti-3-fluoro- and 3-hydroxypyrrolidines.

Krow GR, Edupuganti R, Gandla D, et al. Synthesis of conformationally constrained 5-fluoro- and 5-hydroxymethanopyrrolidines. Ring-puckered mimics of gauche- and anti-3-fluoro- and 3-hydroxypyrrolidines. J Org Chem. 2011;76(10):3626-34. doi:10.1021/jo200117p

Synergistic Effects of Stereochemistry and Appendages on the Performance Diversity of a Collection of Synthetic Compounds.

Melillo B, Zoller J, Hua BK, et al. Synergistic Effects of Stereochemistry and Appendages on the Performance Diversity of a Collection of Synthetic Compounds. J Am Chem Soc. 2018;140(37):11784-11790. doi:10.1021/jacs.8b07319

Stereochemical control of skeletal diversity.

Sello JK, Andreana PR, Lee D, Schreiber SL. Stereochemical control of skeletal diversity. Org Lett. 2003;5(22):4125-7. doi:10.1021/ol035773h

A stereoelectronic effect in prebiotic nucleotide synthesis.

Choudhary A, Kamer KJ, Powner MW, Sutherland JD, Raines RT. A stereoelectronic effect in prebiotic nucleotide synthesis. ACS Chem Biol. 2010;5(7):655-7. doi:10.1021/cb100093g

Generating diverse skeletons of small molecules combinatorially.

Burke MD, Berger EM, Schreiber SL. Generating diverse skeletons of small molecules combinatorially. Science. 2003;302(5645):613-8. doi:10.1126/science.1089946

Diversity-oriented synthesis of 13- to 18-membered macrolactams via ring-closing metathesis.

Dandapani S, Lowe JT, Comer E, Marcaurelle LA. Diversity-oriented synthesis of 13- to 18-membered macrolactams via ring-closing metathesis. J Org Chem. 2011;76(19):8042-8. doi:10.1021/jo2011957

Skeletal diversity via a branched pathway: efficient synthesis of 29 400 discrete, polycyclic compounds and their arraying into stock solutions.

Kwon O, Park SB, Schreiber SL. Skeletal diversity via a branched pathway: efficient synthesis of 29 400 discrete, polycyclic compounds and their arraying into stock solutions. J Am Chem Soc. 2002;124(45):13402-4.

An aldol-based build/couple/pair strategy for the synthesis of medium- and large-sized rings: discovery of macrocyclic histone deacetylase inhibitors.

Marcaurelle LA, Comer E, Dandapani S, et al. An aldol-based build/couple/pair strategy for the synthesis of medium- and large-sized rings: discovery of macrocyclic histone deacetylase inhibitors. J Am Chem Soc. 2010;132(47):16962-76. doi:10.1021/ja105119r

Pathway development and pilot library realization in diversity-oriented synthesis: exploring Ferrier and Pauson-Khand reactions on a glycal template.

Kubota H, Lim J, Depew KM, Schreiber SL. Pathway development and pilot library realization in diversity-oriented synthesis: exploring Ferrier and Pauson-Khand reactions on a glycal template. Chem Biol. 2002;9(2):265-76.