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G3BP-Caprin1-USP10 complexes mediate stress granule condensation and associate with 40S subunits.

Kedersha N, Panas MD, Achorn CA, et al. G3BP-Caprin1-USP10 complexes mediate stress granule condensation and associate with 40S subunits. J Cell Biol. 2016;212(7):845-60. doi:10.1083/jcb.201508028

Novel N-linked aminopiperidine inhibitors of bacterial topoisomerase type II: broad-spectrum antibacterial agents with reduced hERG activity.

Reck F, Alm R, Brassil P, et al. Novel N-linked aminopiperidine inhibitors of bacterial topoisomerase type II: broad-spectrum antibacterial agents with reduced hERG activity. J Med Chem. 2011;54(22):7834-47. doi:10.1021/jm2008826

Inhibition of histone deacetylase 3 protects beta cells from cytokine-induced apoptosis.

Chou DHC, Holson EB, Wagner FF, et al. Inhibition of histone deacetylase 3 protects beta cells from cytokine-induced apoptosis. Chem Biol. 2012;19(6):669-73. doi:10.1016/j.chembiol.2012.05.010

Small-molecule inhibitors of cytokine-mediated STAT1 signal transduction in β-cells with improved aqueous solubility.

Scully SS, Tang AJ, Lundh M, Mosher CM, Perkins KM, Wagner BK. Small-molecule inhibitors of cytokine-mediated STAT1 signal transduction in β-cells with improved aqueous solubility. J Med Chem. 2013;56(10):4125-9. doi:10.1021/jm400397x

Potent and selective inhibitors of Helicobacter pylori glutamate racemase (MurI): pyridodiazepine amines.

Geng B, Basarab G, Comita-Prevoir J, et al. Potent and selective inhibitors of Helicobacter pylori glutamate racemase (MurI): pyridodiazepine amines. Bioorg Med Chem Lett. 2009;19(3):930-6. doi:10.1016/j.bmcl.2008.11.113

Application of a catalytic asymmetric Povarov reaction using chiral ureas to the synthesis of a tetrahydroquinoline library.

Gerard B, O’Shea MW, Donckele E, et al. Application of a catalytic asymmetric Povarov reaction using chiral ureas to the synthesis of a tetrahydroquinoline library. ACS Comb Sci. 2012;14(11):621-30. doi:10.1021/co300098v

Diversity-oriented synthesis-facilitated medicinal chemistry: toward the development of novel antimalarial agents.

Comer E, Beaudoin JA, Kato N, et al. Diversity-oriented synthesis-facilitated medicinal chemistry: toward the development of novel antimalarial agents. J Med Chem. 2014;57(20):8496-502. doi:10.1021/jm500994n

Discovery of small-molecule modulators of the Sonic Hedgehog pathway.

Schaefer GI, Perez JR, Duvall JR, Stanton BZ, Shamji AF, Schreiber SL. Discovery of small-molecule modulators of the Sonic Hedgehog pathway. J Am Chem Soc. 2013;135(26):9675-80. doi:10.1021/ja400034k

Photochemical activation of TRPA1 channels in neurons and animals.

Kokel D, Cheung CYJ, Mills R, et al. Photochemical activation of TRPA1 channels in neurons and animals. Nat Chem Biol. 2013;9(4):257-63. doi:10.1038/nchembio.1183

Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells.

Lopez-Sambrooks C, Shrimal S, Khodier C, et al. Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells. Nat Chem Biol. 2016;12(12):1023-1030. doi:10.1038/nchembio.2194