Peng LF, Stanton BZ, Maloof N, Wang X, Schreiber SL. Syntheses of aminoalcohol-derived macrocycles leading to a small-molecule binder to and inhibitor of Sonic Hedgehog. Bioorg Med Chem Lett. 2009;19(22):6319-25. doi:10.1016/j.bmcl.2009.09.089
Germain AR, Carmody LC, Nag PP, et al. Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells. Bioorg Med Chem Lett. 2013;23(6):1834-8. doi:10.1016/j.bmcl.2013.01.025
Over B, Matsson P, Tyrchan C, et al. Structural and conformational determinants of macrocycle cell permeability. Nat Chem Biol. 2016;12(12):1065-1074. doi:10.1038/nchembio.2203
Wagner FF, Olson DE, Gale JP, et al. Potent and selective inhibition of histone deacetylase 6 (HDAC6) does not require a surface-binding motif. J Med Chem. 2013;56(4):1772-6. doi:10.1021/jm301355j
Clemons PA, Wilson A, Dančík V, et al. Quantifying structure and performance diversity for sets of small molecules comprising small-molecule screening collections. Proc Natl Acad Sci U S A. 2011;108(17):6817-22. doi:10.1073/pnas.1015024108
Mulrooney CA, Lahr DL, Quintin MJ, et al. An informatic pipeline for managing high-throughput screening experiments and analyzing data from stereochemically diverse libraries. J Comput Aided Mol Des. 2013;27(5):455-68. doi:10.1007/s10822-013-9641-y
Tanikawa T, Fridman M, Zhu W, et al. Using biological performance similarity to inform disaccharide library design. J Am Chem Soc. 2009;131(14):5075-83. doi:10.1021/ja806583y
Olson DE, Wagner FF, Kaya T, et al. Discovery of the first histone deacetylase 6/8 dual inhibitors. J Med Chem. 2013;56(11):4816-20. doi:10.1021/jm400390r
Wang M, Zuris JA, Meng F, et al. Efficient delivery of genome-editing proteins using bioreducible lipid nanoparticles. Proc Natl Acad Sci U S A. 2016;113(11):2868-73. doi:10.1073/pnas.1520244113
Kawate T, Iwase N, Shimizu M, et al. Synthesis and structure-activity relationships of phenyl-substituted coumarins with anti-tubercular activity that target FadD32. Bioorg Med Chem Lett. 2013;23(22):6052-9. doi:10.1016/j.bmcl.2013.09.035