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Stanley Center Therapeutics

Genome-wide CRISPR screen in a mouse model of tumor growth and metastasis.

1.

Chen S, Sanjana NE, Zheng K, et al. Genome-wide CRISPR screen in a mouse model of tumor growth and metastasis. Cell. 2015;160(6):1246-60. doi:10.1016/j.cell.2015.02.038.

NF-κB induces miR-148a to sustain TGF-β/Smad signaling activation in glioblastoma.

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Wang H, Pan J-Q, Luo L, et al. NF-κB induces miR-148a to sustain TGF-β/Smad signaling activation in glioblastoma. Mol Cancer. 2015;14:2. doi:10.1186/1476-4598-14-2.

Erratum: Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons.

1.

Yoshimizu T, Pan JQ, Mungenast AE, et al. Erratum: Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons. Mol Psychiatry. 2015;20(2):284. doi:10.1038/mp.2014.181.

Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons.

1.

Yoshimizu T, Pan JQ, Mungenast AE, et al. Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons. Mol Psychiatry. 2015;20(2):162-9. doi:10.1038/mp.2014.143.

Kinetically Selective Inhibitors of Histone Deacetylase 2 (HDAC2) as Cognition Enhancers.

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Wagner FF, Zhang Y-L, Fass DM, et al. Kinetically Selective Inhibitors of Histone Deacetylase 2 (HDAC2) as Cognition Enhancers. Chem Sci. 2015;6(1):804-815. doi:10.1039/C4SC02130D.

Hydroxamic acid-based histone deacetylase (HDAC) inhibitors can mediate neuroprotection independent of HDAC inhibition.

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Sleiman SF, Olson DE, Bourassa MW, et al. Hydroxamic acid-based histone deacetylase (HDAC) inhibitors can mediate neuroprotection independent of HDAC inhibition. J Neurosci. 2014;34(43):14328-37. doi:10.1523/JNEUROSCI.1010-14.2014.

An unbiased approach to identify endogenous substrates of "histone" deacetylase 8.

1.

Olson DE, Udeshi ND, Wolfson NA, et al. An unbiased approach to identify endogenous substrates of "histone" deacetylase 8. ACS Chem Biol. 2014;9(10):2210-6. doi:10.1021/cb500492r.

In vivo imaging of histone deacetylases (HDACs) in the central nervous system and major peripheral organs.

1.

Wang C, Schroeder FA, Wey H-Y, et al. In vivo imaging of histone deacetylases (HDACs) in the central nervous system and major peripheral organs. J Med Chem. 2014;57(19):7999-8009. doi:10.1021/jm500872p.

Copy number variation in schizophrenia in Sweden.

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Szatkiewicz JP, O’Dushlaine C, Chen G, et al. Copy number variation in schizophrenia in Sweden. Mol Psychiatry. 2014;19(7):762-73. doi:10.1038/mp.2014.40.

Studies toward the total synthesis of dihydrolycolucine. Preparation of AB and CEF ring fragments.

1.

Cash BM, Prevost N, Wagner FF, Comins DL. Studies toward the total synthesis of dihydrolycolucine. Preparation of AB and CEF ring fragments. J Org Chem. 2014;79(12):5740-5. doi:10.1021/jo500878v.