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Stanley Center Therapeutics

An inherited duplication at the gene p21 Protein-Activated Kinase 7 (PAK7) is a risk factor for psychosis.

1.

Morris DW, Pearson RD, Cormican P, et al. An inherited duplication at the gene p21 Protein-Activated Kinase 7 (PAK7) is a risk factor for psychosis. Hum Mol Genet. 2014;23(12):3316-26. doi:10.1093/hmg/ddu025.

Pilot investigation of isradipine in the treatment of bipolar depression motivated by genome-wide association.

1.

Ostacher MJ, Iosifescu DV, Hay A, Blumenthal SR, Sklar P, Perlis RH. Pilot investigation of isradipine in the treatment of bipolar depression motivated by genome-wide association. Bipolar Disord. 2014;16(2):199-203. doi:10.1111/bdi.12143.

De novo mutations in schizophrenia implicate synaptic networks.

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Fromer M, Pocklington AJ, Kavanagh DH, et al. De novo mutations in schizophrenia implicate synaptic networks. Nature. 2014;506(7487):179-84. doi:10.1038/nature12929.

A polygenic burden of rare disruptive mutations in schizophrenia.

1.

Purcell SM, Moran JL, Fromer M, et al. A polygenic burden of rare disruptive mutations in schizophrenia. Nature. 2014;506(7487):185-90. doi:10.1038/nature12975.

Development of a high-throughput AlphaScreen assay for modulators of synapsin I phosphorylation in primary neurons.

1.

Chan B, Cottrell JR, Li B, et al. Development of a high-throughput AlphaScreen assay for modulators of synapsin I phosphorylation in primary neurons. J Biomol Screen. 2014;19(2):205-14. doi:10.1177/1087057113505905.

Regulation of glutamate receptor internalization by the spine cytoskeleton is mediated by its PKA-dependent association with CPG2.

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Loebrich S, Djukic B, Tong ZJ, Cottrell JR, Turrigiano GG, Nedivi E. Regulation of glutamate receptor internalization by the spine cytoskeleton is mediated by its PKA-dependent association with CPG2. Proc Natl Acad Sci U S A. 2013;110(47):E4548-56. doi:10.1073/pnas.1318860110.

Small molecule inhibitors of zinc-dependent histone deacetylases.

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Wagner FF, Weїwer M, Lewis MC, Holson EB. Small molecule inhibitors of zinc-dependent histone deacetylases. Neurotherapeutics. 2013;10(4):589-604. doi:10.1007/s13311-013-0226-1.

Genome-wide association analysis identifies 13 new risk loci for schizophrenia.

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Ripke S, O’Dushlaine C, Chambert K, et al. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nat Genet. 2013;45(10):1150-9. doi:10.1038/ng.2742.

Therapeutic potential of isoform selective HDAC inhibitors for the treatment of schizophrenia.

1.

Weïwer M, Lewis MC, Wagner FF, Holson EB. Therapeutic potential of isoform selective HDAC inhibitors for the treatment of schizophrenia. Future Med Chem. 2013;5(13):1491-508. doi:10.4155/fmc.13.141.

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs.

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Cross-Disorder Group of the Psychiatric Genomics Consortium, Lee H, Ripke S, et al. Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet. 2013;45(9):984-94. doi:10.1038/ng.2711.