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Stanley Center Therapeutics

Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder.

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Bergen SE, O’Dushlaine CT, Ripke S, et al. Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder. Mol Psychiatry. 2012;17(9):880-6. doi:10.1038/mp.2012.73.

Regulation of N-type voltage-gated calcium channels and presynaptic function by cyclin-dependent kinase 5.

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Su SC, Seo J, Pan JQ, et al. Regulation of N-type voltage-gated calcium channels and presynaptic function by cyclin-dependent kinase 5. Neuron. 2012;75(4):675-87. doi:10.1016/j.neuron.2012.06.023.

Discovery of Potent and Highly Selective Inhibitors of GSK3b

GWA study data mining and independent replication identify cardiomyopathy-associated 5 (CMYA5) as a risk gene for schizophrenia.

1.

Chen X, Lee G, Maher BS, et al. GWA study data mining and independent replication identify cardiomyopathy-associated 5 (CMYA5) as a risk gene for schizophrenia. Mol Psychiatry. 2011;16(11):1117-29. doi:10.1038/mp.2010.96.

Advancing drug discovery for schizophrenia.

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Marder SR, Roth B, Sullivan PF, et al. Advancing drug discovery for schizophrenia. Ann N Y Acad Sci. 2011;1236:30-43. doi:10.1111/j.1749-6632.2011.06216.x.

AAK1 identified as an inhibitor of neuregulin-1/ErbB4-dependent neurotrophic factor signaling using integrative chemical genomics and proteomics.

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Kuai L, Ong S-E, Madison JM, et al. AAK1 identified as an inhibitor of neuregulin-1/ErbB4-dependent neurotrophic factor signaling using integrative chemical genomics and proteomics. Chem Biol. 2011;18(7):891-906. doi:10.1016/j.chembiol.2011.03.017.

AKT kinase activity is required for lithium to modulate mood-related behaviors in mice.

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Pan JQ, Lewis MC, Ketterman JK, et al. AKT kinase activity is required for lithium to modulate mood-related behaviors in mice. Neuropsychopharmacology. 2011;36(7):1397-411. doi:10.1038/npp.2011.24.

Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder.

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Liu Y, Blackwood DH, Caesar S, et al. Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder. Mol Psychiatry. 2011;16(1):2-4. doi:10.1038/mp.2009.107.

A system for performing high throughput assays of synaptic function.

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Hempel CM, Sivula M, Levenson JM, et al. A system for performing high throughput assays of synaptic function. PLoS One. 2011;6(10):e25999. doi:10.1371/journal.pone.0025999.

Hdac3 is essential for the maintenance of chromatin structure and genome stability.

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Bhaskara S, Knutson SK, Jiang G, et al. Hdac3 is essential for the maintenance of chromatin structure and genome stability. Cancer Cell. 2010;18(5):436-47. doi:10.1016/j.ccr.2010.10.022.