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Chemical Biology and Therapeutics Science Program
Dorr BM, Ham HO, An C, Chaikof EL, Liu DR. Reprogramming the specificity of sortase enzymes. Proc Natl Acad Sci U S A. 2014;111(37):13343-8. doi:10.1073/pnas.1411179111
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Wawer MJ, Jaramillo DE, Dančík V, et al. Automated Structure-Activity Relationship Mining: Connecting Chemical Structure to Biological Profiles. J Biomol Screen. 2014;19(5):738-48. doi:10.1177/1087057114530783
Guilinger JP, Thompson DB, Liu DR. Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification. Nat Biotechnol. 2014;32(6):577-82. doi:10.1038/nbt.2909
Dančík V, Carrel H, Bodycombe NE, et al. Connecting Small Molecules with Similar Assay Performance Profiles Leads to New Biological Hypotheses. J Biomol Screen. 2014;19(5):771-81. doi:10.1177/1087057113520226
Guilinger JP, Pattanayak V, Reyon D, et al. ӳý specificity profiling of TALENs results in engineered nucleases with improved DNA-cleavage specificity. Nat Methods. 2014;11(4):429-35. doi:10.1038/nmeth.2845
Carlson JC, Badran AH, Guggiana-Nilo DA, Liu DR. Negative selection and stringency modulation in phage-assisted continuous evolution. Nat Chem Biol. 2014;10(3):216-22. doi:10.1038/nchembio.1453
McGregor LM, Jain T, Liu DR. Identification of ligand-target pairs from combined libraries of small molecules and unpurified protein targets in cell lysates. J Am Chem Soc. 2014;136(8):3264-70. doi:10.1021/ja412934t