Li H, Ma T, Remsberg JR, et al. Assigning functionality to cysteines by base editing of cancer dependency genes. Nature chemical biology. 2023. doi:10.1038/s41589-023-01428-w
Chemical Biology and Therapeutics Science Program
Peterson AA, Liu DR. Small-molecule discovery through DNA-encoded libraries. Nature reviews. Drug discovery. 2023. doi:10.1038/s41573-023-00713-6
Tao Y, Lamas V, Du W, et al. Treatment of monogenic and digenic dominant genetic hearing loss by CRISPR-Cas9 ribonucleoprotein delivery in vivo. Nature communications. 2023;14(1):4928. doi:10.1038/s41467-023-40476-7
Arbab M, Matuszek Z, Kray KM, et al. Base editing rescue of spinal muscular atrophy in cells and in mice. Science (New York, N.Y.). 2023:eadg6518. doi:10.1126/science.adg6518
Davis JR, Banskota S, Levy JM, et al. Efficient prime editing in mouse brain, liver and heart with dual AAVs. Nature biotechnology. 2023. doi:10.1038/s41587-023-01758-z
Kabra M, Shahi PK, Wang Y, et al. Nonviral base editing of KCNJ13 mutation preserves vision in a model of inherited retinal channelopathy. The Journal of clinical investigation. 2023;133(19). doi:10.1172/JCI171356
Chen L, Hong M, Luan C, et al. Adenine transversion editors enable precise, efficient A•T-to-C•G base editing in mammalian cells and embryos. Nature biotechnology. 2023. doi:10.1038/s41587-023-01821-9
Nguyen TM, Sreekanth V, Deb A, et al. Proteolysis-targeting chimeras with reduced off-targets. Nature chemistry. 2023. doi:10.1038/s41557-023-01379-8
Joynt AT, Kavanagh EW, Newby GA, et al. Protospacer modification improves base editing of a canonical splice site variant and recovery of CFTR function in human airway epithelial cells. Molecular therapy. Nucleic acids. 2023;33:335-350. doi:10.1016/j.omtn.2023.06.020
Lue NZ, Garcia EM, Ngan K, Lee C, Doench JG, Liau BB. Base editor scanning charts the DNMT3A activity landscape. Nature chemical biology. 2023;19(2):176-186. doi:10.1038/s41589-022-01167-4