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Chemical Biology and Therapeutics Science Program
Krishnamurthy S, Traore S, Cooney AL, et al. Functional correction of CFTR mutations in human airway epithelial cells using adenine base editors. Nucleic acids research. 2021;49(18):10558-10572. doi:10.1093/nar/gkab788
Modell AE, Lai S, Nguyen TM, Choudhary A. Bifunctional modalities for repurposing protein function. Cell chemical biology. 2021;28(7):1081-1089. doi:10.1016/j.chembiol.2021.06.005
Blum T, Liu H, Packer MS, et al. Phage-assisted evolution of botulinum neurotoxin proteases with reprogrammed specificity. Science (New York, N.Y.). 2021;371(6531):803-810. doi:10.1126/science.abf5972
Huang TP, Newby GA, Liu DR. Precision genome editing using cytosine and adenine base editors in mammalian cells. Nature protocols. 2021;16(2):1089-1128. doi:10.1038/s41596-020-00450-9
Newby GA, Liu DR. In vivo somatic cell base editing and prime editing. Molecular therapy : the journal of the American Society of Gene Therapy. 2021;29(11):3107-3124. doi:10.1016/j.ymthe.2021.09.002
Gao P, Lyu Q, Ghanam A, et al. Prime editing in mice reveals the essentiality of a single base in driving tissue-specific gene expression. Genome biology. 2021;22(1):83. doi:10.1186/s13059-021-02304-3
Podracky CJ, An C, DeSousa A, Dorr BM, Walsh D, Liu DR. Laboratory evolution of a sortase enzyme that modifies amyloid-β protein. Nature chemical biology. 2021;17(3):317-325. doi:10.1038/s41589-020-00706-1
Shen MW, Zhao KT, Liu DR. Reconstruction of evolving gene variants and fitness from short sequencing reads. Nature chemical biology. 2021;17(11):1188-1198. doi:10.1038/s41589-021-00876-6
Newby GA, Yen JS, Woodard K, et al. Base editing of haematopoietic stem cells rescues sickle cell disease in mice. Nature. 2021;595(7866):295-302. doi:10.1038/s41586-021-03609-w