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Chemical Biology and Therapeutics Science Program

Polycomb-lamina antagonism partitions heterochromatin at the nuclear periphery.

Siegenfeld AP, Roseman S, Roh H, et al. Polycomb-lamina antagonism partitions heterochromatin at the nuclear periphery. Nature communications. 2022;13(1):4199. doi:10.1038/s41467-022-31857-5

Synthetic Reprogramming of Kinases Expands Cellular Activities of Proteins.

Shoba VM, Godage DNPM, Chaudhary SK, Deb A, Siriwardena SU, Choudhary A. Synthetic Reprogramming of Kinases Expands Cellular Activities of Proteins. Angewandte Chemie (International ed. in English). 2022;61(29):e202202770. doi:10.1002/anie.202202770

CRISPR-based therapeutics: current challenges and future applications.

Modell AE, Lim D, Nguyen TM, Sreekanth V, Choudhary A. CRISPR-based therapeutics: current challenges and future applications. Trends in pharmacological sciences. 2022;43(2):151-161. doi:10.1016/j.tips.2021.10.012

ABE8e adenine base editor precisely and efficiently corrects a recurrent COL7A1 nonsense mutation.

Sheriff A, Guri I, Zebrowska P, et al. ABE8e adenine base editor precisely and efficiently corrects a recurrent COL7A1 nonsense mutation. Scientific reports. 2022;12(1):19643. doi:10.1038/s41598-022-24184-8

Enhanced prime editing systems by manipulating cellular determinants of editing outcomes.

Chen PJ, Hussmann JA, Yan J, et al. Enhanced prime editing systems by manipulating cellular determinants of editing outcomes. Cell. 2021;184(22):5635-5652.e29. doi:10.1016/j.cell.2021.09.018

The Use of Informer Sets in Screening: Perspectives on an Efficient Strategy to Identify New Probes.

Clemons PA, Bittker JA, Wagner FF, et al. The Use of Informer Sets in Screening: Perspectives on an Efficient Strategy to Identify New Probes. SLAS Discov. 2021;26(7):855-861. doi:10.1177/24725552211019410

In vivo base editing rescues Hutchinson-Gilford progeria syndrome in mice.

Koblan LW, Erdos MR, Wilson C, et al. In vivo base editing rescues Hutchinson-Gilford progeria syndrome in mice. Nature. 2021;589(7843):608-614. doi:10.1038/s41586-020-03086-7

Disulfide-compatible phage-assisted continuous evolution in the periplasmic space.

Morrison MS, Wang T, Raguram A, Hemez C, Liu DR. Disulfide-compatible phage-assisted continuous evolution in the periplasmic space. Nature communications. 2021;12(1):5959. doi:10.1038/s41467-021-26279-8

Mechanisms of angiogenic incompetence in Hutchinson-Gilford progeria via downregulation of endothelial NOS.

Gete Y, Koblan LW, Mao X, et al. Mechanisms of angiogenic incompetence in Hutchinson-Gilford progeria via downregulation of endothelial NOS. Aging cell. 2021;20(7):e13388. doi:10.1111/acel.13388

PrimeDesign software for rapid and simplified design of prime editing guide RNAs.

Hsu JY, Grünewald J, Szalay R, et al. PrimeDesign software for rapid and simplified design of prime editing guide RNAs. Nature communications. 2021;12(1):1034. doi:10.1038/s41467-021-21337-7