Li C, Georgakopoulou A, Newby GA, et al. In vivo HSC prime editing rescues sickle cell disease in a mouse model. Blood. 2023;141(17):2085-2099. doi:10.1182/blood.2022018252
Chemical Biology and Therapeutics Science Program
Pergu R, Shoba VM, Chaudhary SK, et al. Development and Applications of Chimera Platforms for Tyrosine Phosphorylation. ACS central science. 2023;9(8):1558-1566. doi:10.1021/acscentsci.3c00200
McAuley GE, Yiu G, Chang PC, et al. Human T cell generation is restored in CD3δ severe combined immunodeficiency through adenine base editing. Cell. 2023;186(7):1398-1416.e23. doi:10.1016/j.cell.2023.02.027
Arp CJ, Reynders M, Sreekanth V, et al. Photoswitchable Molecular Glues Enable Optical Control of Transcription Factor Degradation. bioRxiv : the preprint server for biology. 2023. doi:10.1101/2023.04.09.536172
Lim D, Zhou Q, Cox KJ, et al. A general approach to identify cell-permeable and synthetic anti-CRISPR small molecules. Nat Cell Biol. 2022. doi:10.1038/s41556-022-01005-8
Small JC, Joblin-Mills A, Carbone K, et al. Phenotypic Screening for Small Molecules that Protect β-Cells from Glucolipotoxicity. ACS Chem Biol. 2022. doi:10.1021/acschembio.2c00052
Yamada K, Deb A, Shoba VM, et al. Rational Design of Silicon-Based Zinc Ionophores. Angew Chem Int Ed Engl. 2022:e202201698. doi:10.1002/anie.202201698
Siegenfeld AP, Roseman S, Roh H, et al. Polycomb-lamina antagonism partitions heterochromatin at the nuclear periphery. Nature communications. 2022;13(1):4199. doi:10.1038/s41467-022-31857-5
Shoba VM, Godage DNPM, Chaudhary SK, Deb A, Siriwardena SU, Choudhary A. Synthetic Reprogramming of Kinases Expands Cellular Activities of Proteins. Angewandte Chemie (International ed. in English). 2022;61(29):e202202770. doi:10.1002/anie.202202770
Modell AE, Lim D, Nguyen TM, Sreekanth V, Choudhary A. CRISPR-based therapeutics: current challenges and future applications. Trends in pharmacological sciences. 2022;43(2):151-161. doi:10.1016/j.tips.2021.10.012