Publications

Stanley Center Therapeutics

Selective inhibition of glycogen synthase kinase 3α corrects pathophysiology in a mouse model of fragile X syndrome.

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McCamphill PK, Stoppel LJ, Senter RK, et al. Selective inhibition of glycogen synthase kinase 3α corrects pathophysiology in a mouse model of fragile X syndrome. Sci Transl Med. 2020;12(544). doi:10.1126/scitranslmed.aam8572.

Effects of a patient-derived de novo coding alteration of CACNA1I in mice connect a schizophrenia risk gene with sleep spindle deficits.

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Ghoshal A, Uygun DS, Yang L, et al. Effects of a patient-derived de novo coding alteration of CACNA1I in mice connect a schizophrenia risk gene with sleep spindle deficits. Transl Psychiatry. 2020;10(1):29. doi:10.1038/s41398-020-0685-1.

Multiplexed and high-throughput neuronal fluorescence imaging with diffusible probes.

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Guo S-M, Veneziano R, Gordonov S, et al. Multiplexed and high-throughput neuronal fluorescence imaging with diffusible probes. Nat Commun. 2019;10(1):4377. doi:10.1038/s41467-019-12372-6.

Entropy as a Driver of Selectivity for Inhibitor Binding to Histone Deacetylase 6.

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Porter NJ, Wagner FF, Christianson DW. Entropy as a Driver of Selectivity for Inhibitor Binding to Histone Deacetylase 6. Biochemistry. 2018;57(26):3916-3924. doi:10.1021/acs.biochem.8b00367.

Progress in Understanding and Treating SCN2A-Mediated Disorders.

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Sanders SJ, Campbell AJ, Cottrell JR, et al. Progress in Understanding and Treating SCN2A-Mediated Disorders. Trends Neurosci. 2018;41(7):442-456. doi:10.1016/j.tins.2018.03.011.

Effects of 3D culturing conditions on the transcriptomic profile of stem-cell-derived neurons.

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Tekin H, Simmons S, Cummings B, et al. Effects of 3D culturing conditions on the transcriptomic profile of stem-cell-derived neurons. Nat Biomed Eng. 2018;2(7):540-554. doi:10.1038/s41551-018-0219-9.

Comprehensive comparative analysis of 5'-end RNA-sequencing methods.

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Adiconis X, Haber AL, Simmons SK, et al. Comprehensive comparative analysis of 5’-end RNA-sequencing methods. Nat Methods. 2018;15(7):505-511. doi:10.1038/s41592-018-0014-2.

Functionally Biased D2R Antagonists: Targeting the β-Arrestin Pathway to Improve Antipsychotic Treatment.

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Weïwer M, Xu Q, Gale JP, et al. Functionally Biased D2R Antagonists: Targeting the β-Arrestin Pathway to Improve Antipsychotic Treatment. ACS Chem Biol. 2018;13(4):1038-1047. doi:10.1021/acschembio.8b00168.

Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia.

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Wagner FF, Benajiba L, Campbell AJ, et al. Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia. Sci Transl Med. 2018;10(431). doi:10.1126/scitranslmed.aam8460.

Developing High-Throughput Assays to Analyze and Screen Electrophysiological Phenotypes.

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Pan JQ, Baez-Nieto D, Allen A, Wang H-R, Cottrell JR. Developing High-Throughput Assays to Analyze and Screen Electrophysiological Phenotypes. Methods Mol Biol. 2018;1787:235-252. doi:10.1007/978-1-4939-7847-2_18.